1887

Abstract

SUMMARY

The inactivation of Semliki Forest virus by hydroxylamine was a first-order reaction. The ability of the partially inactivated virus to induce the production of infective virus, virus haemagglutinin, virus-induced RNA synthesis, virus-induced RNA polymerase and interferon were all inactivated with first-order kinetics. It is concluded that functional nucleic acid is essential for interferon production in this system.

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1968-07-01
2022-01-28
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References

  1. Burke D. C. 1966; The production of interferon by viruses: mechanisms. In Interferons p. 55 Ed. by Finter N. B. Amsterdam: North Holland Publishing Co;
    [Google Scholar]
  2. Burke D. C., Buchan A. 1965; Interferon production in chick embryo cells. I. Production by ultraviolet-inactivated virus. Virology 26:28
    [Google Scholar]
  3. Burke D. C., Skehel J. J., Low M. 1967; Interferon production and viral ribonucleic acid synthesis in chick embryo cells. J. gen. Virol 1:235
    [Google Scholar]
  4. Cheng P. Y. 1961; Purification, size and morphology of a mosquito-borne animal virus, Semliki Forest virus. Virology 14:124
    [Google Scholar]
  5. Clarke D. H., Casals J. 1958; Techniques for haemagglutination and haemagglutination-inhibition with anthropod-borne viruses. Am. J. trop. med. Hyg 7:561
    [Google Scholar]
  6. Franklin R. M., Wecker E. 1959; Inactivation of some animal viruses by hydroxylamine and the structure of ribonucleic acid. Nature, Lond 184:343
    [Google Scholar]
  7. Holland J. J., McClaren L. C., Hoyer B. H., Syverton J. T. 1960; Enteroviral ribonucleic acid. II. Biological, physical and chemical studies. J. exp. Med 112:841
    [Google Scholar]
  8. Kozloff L. M., Lute M., Henderson K. 1957; Viral invasion. I. Rupture of thiol ester bonds in the bacteriophage tail. J. biol. Chem 228:511
    [Google Scholar]
  9. Lampson G. P., Tytell A. A., Field A. K., Nemes M. M., Hilleman M. R. 1967; Inducers of interferon and host resistance. Double-stranded RNA from extracts of. Penicillium funi-culosom. Proc. natn. Acad. Sci., U. S. A. 58:782
    [Google Scholar]
  10. Martin E. M., Sonnabend J. A. 1967; Ribonucleic acid polymerase catalyzing synthesis of double-stranded arbovirus ribonucleic acid. J. Virol 1:97
    [Google Scholar]
  11. Mécs E., Sonnabend J. A., Martin E. M., Fantes K. H. 1967; The effect of interferon on the synthesis of RNA in chick cells infected with Semliki Forest virus. J. gen. Virol 1:25
    [Google Scholar]
  12. Phillips J. H., Brown D. M., Adman R., Grossman L. 1965; The effects of hydroxylamine on polynucleotide templates for RNA polymerase. J. molec. Biol 12:816
    [Google Scholar]
  13. Schäfer W., Rott R. 1962; Herstellung von Virusvaccinen mit Hydroxylamin. Z. Hyg. Infekt-Krankh 148:256
    [Google Scholar]
  14. Scholtissek C., Rott R. 1964; Behaviour of virus-specific activities in tissue cultures infected with myxoviruses after chemical changes of the viral ribonucleic acid. Virology 22:169
    [Google Scholar]
  15. Schuster H. 1961; The reaction of tobacco mosaic virus ribonucleic acid with hydroxylamine. J. molec. Biol 3:447
    [Google Scholar]
  16. Skehel J. J., Burke D. C. 1967; Virus nucleic acid and interferon formation. Biochem. J 103:71 p
    [Google Scholar]
  17. Skehel J. J., Hay A. J., Burke D. C., Cartwright L. N. 1967; Effects of actinomycin D and 2-mercapto-I-(β-4 pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells. Biochim. biophys. Acta 142:430
    [Google Scholar]
  18. Walters S., Burke D. C., Skehel J. J. 1967; Interferon production and RNA inhibitors. J. gen Virol 1:349
    [Google Scholar]
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