1887

Abstract

SUMMARY

Initiation of treatment with potent interferon preparations (6.4 × 10 units per dose) 4 days after intranasal inoculation of VSV (at a time when virus has already multiplied in the brains of most mice) resulted in a marked increase in mouse survival. In a series of 6 experiments only 11 to 18% of control mice survived whereas 52% of interferon treated mice survived. These results suggest the usefulness of exogenous interferon even when treatment is begun late in the course of an acute virus disease.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-27-3-395
1975-06-01
2022-01-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/27/3/JV0270030395.html?itemId=/content/journal/jgv/10.1099/0022-1317-27-3-395&mimeType=html&fmt=ahah

References

  1. Billiau A., Muyembe J. J., De Somer P. 1971; Effect of chlorite-oxidized oxylamylose on influenza virus infection in mice. American Society for Microbiology 21:580–584
    [Google Scholar]
  2. Cerottini J. C., Brunner K. T., Lindahl P., Gresser I. 1973; Inhibitory effect of interferon preparation and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells. Nature New Biology 242152–153
    [Google Scholar]
  3. De Clercq E., De Somer P. 1971; Comparative study of the efficacy of different forms of interferon therapy in the treatment of mice challenged intranasally with vesicular stomatitis (VSV). Proceedings of the Society for Experimental Biology and Medicine 138301–307
    [Google Scholar]
  4. Finter N. B. 1973 Interferons and inducers in vivo. I. Antiviral effects in experimental animals. In Interferons and Interferon Inducers, 2nd edition. pp. 295–360 Edited by Finter N. B. London: NorthHolland Publishing Company;
    [Google Scholar]
  5. Gisler H., Lindahl P., Gresser I. 1972; Effects of interferon on antibody synthesis in vitro. Journal of Immunology 113438–444
    [Google Scholar]
  6. Lellouch p., Lazer P. 1974; Méthodes Statistiques en Expérimentation Biologique. p. 103 édition Flammarion (Médecine-Sciences) Paris.
    [Google Scholar]
  7. Lindahl P., Leary P., Gresser I. 1972; Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 69:721–725
    [Google Scholar]
  8. Lindahl-Magnusson P., Leary P., Gresser I. 1972; Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells. Nature New Biology 73:120–121
    [Google Scholar]
  9. Tovey M., Begon-Lours J., Gresser I. 1974; A method for the large scale production of potent interferon preparations. Proceedings of the Society for Experimental Biology and Medicine 146:809–815
    [Google Scholar]
  10. Worthington M., Levy H., Rice J. 1973; Late therapy of an arbovirus encephalitis in mice with interferon and interferon-stimulators. Proceedings of the Society for Experimental Biology and Medicine 143:638–643
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-27-3-395
Loading
/content/journal/jgv/10.1099/0022-1317-27-3-395
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error