1887

Abstract

Summary

Initiation of treatment with potent interferon preparations (6.4 × 10 units per dose) 4 days after intranasal inoculation of VSV (at a time when virus has already multiplied in the brains of most mice) resulted in a marked increase in mouse survival. In a series of 6 experiments only 11 to 18% of control mice survived whereas 52% of interferon treated mice survived. These results suggest the usefulness of exogenous interferon even when treatment is begun late in the course of an acute virus disease.

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/content/journal/jgv/10.1099/0022-1317-27-3-395
1975-06-01
2019-10-13
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-27-3-395
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