1887

Abstract

SUMMARY

9--methyloxime erythromycin A and its analogue inhibited reverse transcriptase and blocked focus formation of Rous sarcoma virus. These chemicals inhibited neither DNA-dependent DNA polymerase nor DNA-dependent RNA polymerase from bacterial sources. However, they inhibited reverse transcriptase with an apparently different mechanism than that by rifamycin ABDP.

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1975-01-01
2024-12-06
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References

  1. Baltimore D. 1970; RNA-dependent DNA polymerase in the virions of RNA tumor viruses. Nature, London 226:1209–1211
    [Google Scholar]
  2. Duesberg P. H., Canaani E. 1970; Complementarity between Rous sarcoma virus RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase. Virology 42:783–788
    [Google Scholar]
  3. diMauro E., Snyder L., Marino P., Lamberti A., Coppo A., Tocchini-Valentin G. P. 1969; Rifampicin sensitivity of the components of DNA-dependent RNA polymerase. Nature, London 222:533–537
    [Google Scholar]
  4. Garapin A. C., Mcdonnell J. P., Levinson W. E., Quintrell N., Fanshier L., Bishop J. M. 1970; DNA polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product. Journal of Virology 6:589–598
    [Google Scholar]
  5. Hanafusa H., Hanafusa T. 1971; Noninfectious RSV deficient in DNA polymerase. Virology 43:313–316
    [Google Scholar]
  6. Hatanaka M., Huebner R. J., Gilden R. V. 1970; DNA polymerase activity associated with RNA tumor viruses. Proceedings of National Academy of Sciences of the United States of America 67:143–147
    [Google Scholar]
  7. Hobom-Schnegg B., Robinson H. L., Robinson W. S. 1970; Replication of Rous sarcoma virus in synchronized cells. Journal of General Virology 7:85–93
    [Google Scholar]
  8. Hung P. P. 1973; Rescue of chemically inactivated Rous sarcoma virus transforming activity by avian leukosis virus. Virology 53:463–467
    [Google Scholar]
  9. Jones O. W., Berg P. 1966; Studies on the binding of RNA polymerase to polynucleotides. Journal of Molecular Biology 22:199–209
    [Google Scholar]
  10. Linial M., Mason W. S. 1973; Characterization of two conditional early mutants of Rous sarcoma virus. Virology 53:258–273
    [Google Scholar]
  11. Robinson W. S., Robinson H. L. 1972; Inhibition of growth of uninfected and Rous sarcoma virus infected chick embryo fibroblasts by rifampicin. National Cancer Institute Journal 46:785–788
    [Google Scholar]
  12. Rokutanda M., Rokutanda H., Green M., Fujinaga K., Ray R. K., Gurgo C. 1970; Formation of viral RNA-DNA hybrid molecules by the DNA polymerase of sarcoma-leukemia viruses. Nature, London 227:1026–1031
    [Google Scholar]
  13. Scolnick E. M., Aaronson S. A., Todaro O. J. 1970; RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. Proceedings of National Academy of Sciences of the United States of America 67:1789–1796
    [Google Scholar]
  14. Sippel A. E., Hartman G. R. 1970; Rifampicin resistance of RNA polymerase in the binary complex with DNA. European Journal of Biochemistry 16:152–157
    [Google Scholar]
  15. So A. G., Downey K. M. 1970; Studies on the mechanism of ribonucleic acid synthesis II. Stabilization of the DNA-RNA polymerase complex by the formation of a single phosphodiester bond. Biochemistry 9:4788–4793
    [Google Scholar]
  16. Spiegelman S., Burny A., Das M. R., Keydar J., Schlom J., Travnicek M., Watson K. 1970; Synthetic DNA-RNA hybrids and RNA-RNA duplexes as templates for polymerases of the oncogenic RNA viruses. Nature, London 227:563–567
    [Google Scholar]
  17. Temin H. M., Mizutani S. 1970; RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature, London 226:1211–1213
    [Google Scholar]
  18. Ting R. C., Yang S. S., Gallo R. C. 1972; Reverse transcriptase, RNA tumor virus transformation and derivatives of rifamycin sv. Nature, New Biology 236:163–166
    [Google Scholar]
  19. Von der Helm K., Krakow J. S. 1972; Inhibition of RNA polymerase by streptolydigin. Nature, New Biology 236:82–83
    [Google Scholar]
  20. Wang S., Kothari R. M., Taylor M., Hung P. 1973; Transfer RNA activities of Rous sarcoma and Rous associated viruses. Nature, New Biology 242:133–135
    [Google Scholar]
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