1887

Abstract

Summary

Mice can be immunized with the isolated capsid components of adenovirus (fibre and hexon) and the antibody response is largely thymus dependent. Immunized mice are protected against challenge with a lethal dose of adenovirus and this protection is type-specific for fibre, and mostly type-specific for hexon. The protection is antibody-mediated and there is an absolute requirement for a detectable level of circulating antibody to be present at the time of challenge. Although cell-mediated immunity is insufficient to protect against this particular disease syndrome, the possibility of its importance in protecting against natural adenovirus infection remains.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-25-3-325
1974-12-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/25/3/JV0250030325.html?itemId=/content/journal/jgv/10.1099/0022-1317-25-3-325&mimeType=html&fmt=ahah

References

  1. Allison A. C. 1972; Immunity against viruses. Scientific Basis of Medicine Annual Reviews49–73
    [Google Scholar]
  2. Barzilai I. R., Lazarus L. H., Goldblum N. 1972; Viscosity-density gradient for purification of foot and mouth disease virus. Archiv für die gesamte Virusforschung 36:141–146
    [Google Scholar]
  3. Basten A., Howard J. G. 1973a In Current Topics in Immunobiology vol 2265–291 Edited by Davies A. J. S., Carter R. L. New York & London: Plenum Press;
    [Google Scholar]
  4. Couch R. B., Kasel J. A., Pereira H. G., Haase A. T., Knight V. 1973a; Induction of immunity in man by crystalline adenovirus type 5 capsid antigens. Proceedings of the Society for Experimental Biology and Medicine 143:905–910
    [Google Scholar]
  5. Cross A. M., Leuchars E., Davies A. J. S. 1964; Retention of immunological information (II). By thymec-tomised syngeneic radiation chimaeras. Nature, London 203:1042–1045
    [Google Scholar]
  6. Dresser D. W., Phillips J. M. 1973; The cellular targets for the action of adjuvants. T-adjuvants and B-adjuvants. In Immunopotentiation (Ciba Foundation Symposium) 183–28 (New Series) Elsevier-Excerpta Medica, North Holland:
    [Google Scholar]
  7. Feldman M., Basten A. 1971; The relationship between antigenic structure and the requirement for thymus derived cells in the immune response. Journal of Experimental Medicine 134:103–119
    [Google Scholar]
  8. Haase A. T., Mautner V., Pereira H. G. 1972; The immunogenicity of adenovirus type 5 structural proteins. Journal of Immunology 108:483–485
    [Google Scholar]
  9. Hunter W. M., Greenwood F. C. 1962; Preparation of iodine I131 labelled human growth hormone of high specific activity. Nature, London 194:495–496
    [Google Scholar]
  10. Janeway C. A. Jun, Sela M. 1967; Synthetic antigens composed exclusively of l-or D-amino acids, I. Effects of optical configuration on the immunogenicity of synthetic polypeptides in mice. Immunology 13:29–38
    [Google Scholar]
  11. Kaplan H. S. 1950; The influence of thymectomy, splenectomy and gonadectomy on the incidence of radiation induced lymphoid tumours in strain C 57 black mice. Journal of the National Cancer Institute 11:83–90
    [Google Scholar]
  12. Kjellen L., Pereira H. G. 1968; Role of adenovirus antigens in the induction of virus neutralising antibody. Journal of General Virology 2:177–185
    [Google Scholar]
  13. Mautner V., Pereira H. G. 1971; Crystallisation of a second adenovirus protein (the fibre). Nature, London 230:456–457
    [Google Scholar]
  14. Norrby E. 1969; The structural and functional diversity of adenovirus capsid components. Journal of General Virology 5:221–236
    [Google Scholar]
  15. Nossal G. I. V., Ada G. L., Austin C. M. 1964; Antigens in immunity. II. Immunogenic properties of flagella, polymerized flagellin and flagellin in the primary response. Australian Journal of Experimental Biology, Medicine and Science 42:283–294
    [Google Scholar]
  16. Panijel J., Cayeux P. 1968; Immunosuppressive effects of macrophage antiserum. Immunology 14:769–780
    [Google Scholar]
  17. Pereira H. G., Machado R. D., Schild G. C. 1972; Study of adenovirus hexon antigen-antibody reactions by single radial diffusion techniques. Journal of Immunological Methods 2:121–128
    [Google Scholar]
  18. Pereira H. G., Valentine R. C., Russell W. C. 1968; Crystallisation of an adenovirus protein. Nature, London 219:949–947
    [Google Scholar]
  19. Philipson L., Lonberg-Holm K., Pettersson U. 1968; Virus receptor interaction in an adenovirus system. Journal of Virology 2:1064–1075
    [Google Scholar]
  20. Philipson L., Pettersson U. 1973; Structure and function of virion proteins of adenoviruses. Progress in Experimental Tumour Research (Oncogenic adenoviruses) 18:1–55
    [Google Scholar]
  21. Postlethwaite R. 1973; Liver damage induced in mice by human adenovirus type 5. Scottish Medical Journal 18:131
    [Google Scholar]
  22. Raff M. C., Wortis H. H. 1970; Thymus dependence of bearing cells in the peripheral lymphoid tissue of mice. Immunology 18:931–942
    [Google Scholar]
  23. Russell W. C. 1971; Adenovirus specified proteins. In Strategy of the Viral Genome (Ciba Foundation Symposium) 335–353 Edited by Wolstenholme G. E. W., O’Connor M. London: Churchill Livingstone;
    [Google Scholar]
  24. Russell W. C., Valentine R. C., Pereira H. G. 1967; The effect of heat on the anatomy of the adenovirus. Journal of General Virology 1:509–522
    [Google Scholar]
  25. Schmidtke J. K., Unanue E. R. 1971; Macrophage-antigen interaction: uptake, metabolism and im-munogenicity of foreign albumin. Journal of Immunology 107:331–338
    [Google Scholar]
  26. Unanue E. R., Askonas B. A. 1968; The immune response of mice to antigen in macrophages. Immunology 15:287–296
    [Google Scholar]
  27. Wadell G. 1972; Sensitization and neutralisation of adenovirus by specific sera against capsid subunits. Journal of Immunology 108:622–632
    [Google Scholar]
  28. Wilcox W. C., Ginsberg H. S. 1963; Production of specific neutralising antibody with soluble antigens of type 5 adenovirus. Proceedings of the Society for Experimental Biology and Medicine 114:37–42
    [Google Scholar]
  29. Williams J. F. 1970; Enhancement of adenovirus plaque formation on HeLa cells by magnesium chloride. Journal of General Virology 9:251–255
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-25-3-325
Loading
/content/journal/jgv/10.1099/0022-1317-25-3-325
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error