1887

Abstract

SUMMARY

Representative myxoviruses were inactivated by cultures of normal human or mouse lymphoid cells even after stimulation with a variety of mitogens. The fractionation of cells by velocity sedimentation indicated that inactivation occurred in the presence of some lymphocyte populations but not macrophages. Pretreatment with neuraminidase prevented this effect. Cells producing antibody to sheep RBC failed either to adsorb or to inactivate virus. The direct inactivation of myxoviruses by normal lymphoid cells may be one of the mechanisms involved in host resistance against viruses of this group.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-20-2-211
1973-08-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/20/2/JV0200020211.html?itemId=/content/journal/jgv/10.1099/0022-1317-20-2-211&mimeType=html&fmt=ahah

References

  1. Amato D., Cowan D. H., Mcculloch E. A. 1972; Separation of immuno-competent cells from human and mouse haemopoietic cell suspensions by velocity sedimentation. Blood 39:472–480
    [Google Scholar]
  2. Blandford G., Heath R. B. 1972; Studies on the immune response and pathogenesis of Sendai virus infection of mice. I. The fate of viral antigens. Immunology 22:637–649
    [Google Scholar]
  3. Böyum A. 1968; Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Clinical Laboratory Investigation 21: suppl 9777–90
    [Google Scholar]
  4. De Madrid A. T., Porterfield J. S. 1969; A simple micro-culture method for the study of group B Arboviruses. Bulletin of the World Health Organization 40:113–121
    [Google Scholar]
  5. Denman A. M. 1973; Methods for separating human blood mononuclear cell populations. Journal of Immunological Methods (in the press)
    [Google Scholar]
  6. Denman A. M., Pelton B. K. 1972; Separation of lymphoid cells by physical means. In Methods in Cell Preparation Edited by Read B. K. Guildford: University of Surrey Press; (in the press)
    [Google Scholar]
  7. Dwyer J. M., Mackay I. R. 1970; Antigen-binding lymphocytes in human blood. Lancet 1:164–7
    [Google Scholar]
  8. Edwards G. E., Miller R. G., Phillips R. A. 1971; Differentiation of rosette-forming cells from myeloid stem cells. Journal of Immunology 105:719–729
    [Google Scholar]
  9. Eustatia J. M., Van Der Veen J. 1971; Viral replication in cultures of phytohaemagglutinin treated mouse lymphocytes. Proceedings of the Society of Experimental Biology and Medicine 137:424–428
    [Google Scholar]
  10. Greaves M. F., Hogg N. M. 1971; Antigen-binding sites on mouse lymphoid cells. In Cell Interactions and Receptor Antibodies in Immune Responses pp 145–155 Edited by Makala Anne Cross O., Kosunen. T. U. London and New York: Academic Press;
    [Google Scholar]
  11. Hoorn B., Tyrrell D. A. J. 1969; Organ cultures in virology. Progress in Medical Virology 11:408–450
    [Google Scholar]
  12. Janossy G., Greaves M. F. 1971; Lymphocyte activation. I. Response of ‘T’ and ‘B’ lymphocytes to phytomitogens. Clinical and Experimental Immunology 9:483–495
    [Google Scholar]
  13. Mccahon D., Schild G. C. 1972; Segregation of antigenic and biological characteristics during influenza virus recombination. Journal of General Virology 15:73–77
    [Google Scholar]
  14. Merigan T. R., Wheelock E. F. 1971; Virus-lymphocyte interactions. In Progress in Immunology pp 1351–6 Edited by Amos D. B. New York and London: Academic Press;
    [Google Scholar]
  15. Miller R. G., Phillips R. A. 1969; Separation of cells by velocity sedimentation. Journal of Cellular Physiology 73:191–201
    [Google Scholar]
  16. Osoba D. 1970; Some physical and radiobiological properties of immunologically reactive mouse spleen cells. Journal of Experimental Medicine 132:368–383
    [Google Scholar]
  17. Parker J. C., Tennant R. W., Ward T. G. 1966; Prevalence of viruses in mouse colonies. In Viruses of Laboratory Rodents. National Cancer Institute Monograph No. 20 pp 47–53 Edited by Holdenried. R. National Cancer Institute; Bethesda, Maryland, U.S.A:
    [Google Scholar]
  18. Prince A. M., Ginsberg H. S. 1957; Immunohistochemical studies on the interaction between Ehrlich ascites tumour cells and Newcastle Disease virus. Journal of Experimental Medicine 105:177–188
    [Google Scholar]
  19. Reed L. J., Meunch H. S. 1938; A simple method of estimating fifty per-cent and points. American Journal of Hygiene 27:493–497
    [Google Scholar]
  20. Robinson T. W. E., Cltreton R. J. R., Heath R. B. 1968; The pathogenesis of Sendai virus infection in the mouse lung. Journal of Medical Microbiology 1:89–95
    [Google Scholar]
  21. Roitt I. M., Greaves M. F., Torrigiani G., Brostoff J., Playfair J. H. L. 1969; The cellular basis of immunological responses. Lancet 11:367–371
    [Google Scholar]
  22. Tovell D., Cantell K. 1971; Kinetics of interferon production in human leukocyte suspensions. Journal of General Virology 13:485–489
    [Google Scholar]
  23. Wigzell H., Anderson B. 1969; Cell separation on antigen coated columns: elimination of high-rate antibody forming cells and immunological memory cells. Journal of Experimental Medicine 129:23–26
    [Google Scholar]
  24. Woodruff J. F., Woodruff J. J. 1972; Virus-induced alterations of lymphoid tissues. II. Lymphocyte receptors for Newcastle Disease virus. Cellular Immunology 5:296–306
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-20-2-211
Loading
/content/journal/jgv/10.1099/0022-1317-20-2-211
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error