1887

Abstract

Summary

Serological relationships between neuraminidases of representative strains of influenza virus isolated between 1930 and 1967 were studied, using rabbit antisera. The neuraminidases of type A strains formed three antigenic groups, , A0-A1 and A2, with antigenic drift within these groups. The neuraminidases of type B strains were unrelated to those of type A strains, and also showed antigenic drift. Four subgroups could be distinguished in haemagglutination-inhibition tests, , Ao, A1 and A2. Antigenic drift occurred within each of these subgroups; antigenic changes in the neuraminidase and haemagglutinin occurred independently.

The neuraminidases of different strains as well as variants of a single strain varied greatly in their heat stability, which had no direct relation to the antigenic changes or the time of isolation of the strains. Both the antigenicity and the enzymic activity of the neuraminidases of certain strains () were heat-labile and it was necessary to use freshly prepared virus suspensions for preparing antisera to their neuraminidases.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-2-3-385
1968-05-01
2022-01-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/2/3/JV0020030385.html?itemId=/content/journal/jgv/10.1099/0022-1317-2-3-385&mimeType=html&fmt=ahah

References

  1. Ada G. L., Lind P. E., Laver E. G. 1963; An immunological study of avian, viral and bacterial neuraminidase based on specific inhibition of enzyme by antibody. J. gen. Microbiol 32:225
    [Google Scholar]
  2. Aminoff D. 1961; Methods for the quantitative estimation of W-acetyl neuraminic acid and their application to hydrolysates of sialomucoids. Biochem. J 81:384
    [Google Scholar]
  3. Anderson S. G., Burnet F. M. 1947; Sporadic and minor epidemic incidence of influenza A in Victoria, 1945-46. I. Phase behaviour of influenza A strains in relation to epidemic characteristics. J. exp. Biol. med. Sci 25:235
    [Google Scholar]
  4. Andrewes C. H. 1959; Asian influenza: a challenge to epidemiology. In Perspectives in Virology p 184 1: Pollard M. edited by John Wiley and Sons; New York:
    [Google Scholar]
  5. Burnet F. M. 1935; Influenza virus isolated from an Australian epidemic. A ust. J. Med 2:651
    [Google Scholar]
  6. Burnet F. M. 1951; A genetic approach to variation in influenza viruses. 1. The characters of three substrains of influenza virus A (WS). J. gen. Microbiol 5:46
    [Google Scholar]
  7. Burnet F. M. 1955 Principles of Animal Virology p 380 New York: Academic Press Inc;
    [Google Scholar]
  8. Choppin P. W., Tamm I. 1959; Two kinds of particles with contrasting properties in influenza A virus strains from the 1957 pandemic. Virology 8:539
    [Google Scholar]
  9. Drzeniek R., Seto J. T., Rott R. 1966; Characterization of neuraminidases from myxoviruses. Biochim. biophys. Acta 128:547
    [Google Scholar]
  10. Fazekasdestgroth S., Graham D. M., Jack I. 1958; The serology of mumps infection. 1. new source of antigen and a simplified complement-fixation test. J. lab. clin. Med 51:883
    [Google Scholar]
  11. Fazekasdestgroth S., Withell J., Lafferty K. J. 1958; An improved assay method neutralizing antibodies against influenza viruses. J. Hyg., Comb 56:415
    [Google Scholar]
  12. Francis T. 1940; A new type of virus from epidemic influenza. Science; N.Y: 92405
    [Google Scholar]
  13. Francis T., Maassab H. F. 1965; Influenza viruses. In Viral and Rickettsial Infections of Man, 4th ed.689 Horsfall F. L., Tamm I. Philadelphia: J. B. Lippincott Co; Edited by
    [Google Scholar]
  14. Francis T., Magill T. P. 1935; Immunological studies with the virus of influenza. J. exp. Biol 62:505
    [Google Scholar]
  15. Graham E.R.B. 1961; Some aspects of the structure of the carbohydrate moiety of fetuin. Aust. J. Sci 24:140
    [Google Scholar]
  16. Green I. J., Hung S. C., Yu P. S., Lee G. W., Pereira H. G. 1964; The isolation and characterization of a new influenza Type B virus on Taiwan. Am. J. Hyg 79:107
    [Google Scholar]
  17. Jensen K. E. 1957; The nature of serological relationships among influenza viruses. Adv. Virus Res 4:279
    [Google Scholar]
  18. Laver W. G. 1963; The structure of influenza viruses 3. Disruption of the virus particles and separation of neuraminidase activity. Virology 20:251
    [Google Scholar]
  19. Laver W. G., Kilbourne E. D. 1966; Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology 20:493
    [Google Scholar]
  20. Mayron L. W., Robert B., Winzler R. J., Rafelson M. E. 1961; Studies on the neuraminidase of influenza virus 1, Separation and some properties of the enzyme from Asian and PR 8 strains. Archs Biochem. Biophys 92:475
    [Google Scholar]
  21. Rafelson M. E., Wilson V. W., Schneir M. 1962; The neuraminidase of influenza virus. Presbyterian St Luke's Hospital Medical Bulletin, Chicago 1:34
    [Google Scholar]
  22. Rasmussen A. F. 1964; Avian myxoviruses and man. In Newcastle disease virus p 313 Hanson R. P. Edited by
    [Google Scholar]
  23. Rasmussen A. F., Stokes J. C., Smadel J. E. 1948; Army experience with influenza 1946-1947: laboratory aspects. Am. J. Hyg 47:142
    [Google Scholar]
  24. Seto J. T., Rott R. 1966; Functional significance of sialidase during influenza virus multiplication. Virology 30:731
    [Google Scholar]
  25. Seto J. T., Drzeniek R., Rott R. 1966; Isolation of a low molecular weight sialidase (neuraminidase) from influenza virus. Biochim. biophys. Acta 113:402
    [Google Scholar]
  26. Seto J. T., Hickey B. J., Rasmussen A. F. 1959; Sialidase activity and related properties of influenza A2 viruses. Virology 9:598
    [Google Scholar]
  27. Shope R. E. 1931; Swine influenza. Experimental transmission and pathology. J. exp. Med 54:349
    [Google Scholar]
  28. Stuart-HARRIS C. H. 1939; A neurotropic strain of human influenza virus. Lancet 1:497
    [Google Scholar]
  29. Tozawa H., Homma M., Ishida N. 1967; Specificity of a neuraminidase activity of Sendai virus. Proc. Soc. exp. Biol. Med 124:734
    [Google Scholar]
  30. Warren L. 1959; The thiobarbituric acid assay of sialic acids. J. biol. Chem 234:1971
    [Google Scholar]
  31. Wilson V. W., Rafelson M. E. 1963; Isolation of neuraminidase from influenza virus. Biochem Prep 10:113
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-2-3-385
Loading
/content/journal/jgv/10.1099/0022-1317-2-3-385
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error