1887

Abstract

Summary

A quantitative immunofluorescent cell-counting technique was used to investigate the virustatic effect of aminoadamantane, ammonium acetate and a number of aliphatic amines on the development of influenza virus antigens in BHK-21 cell monolayers. Influenza virus strains A2//49/57, A/ and B//939/59 were used at high multiplicities of infection in the tests. Quantification of the activity of the antiviral compounds was provided by the direct estimation of the proportion of infected cells in which the production of influenza virus fluorescent antigens was blocked. Comparable results were obtained for A2//49/57 virus using the immunofluorescent technique and the more conventional method of measuring antiviral activity by the reduction in the ability of the virus to multiply in tissue culture in the presence of the test compounds.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-2-3-377
1968-05-01
2019-10-22
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-2-3-377
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error