The virus of has long been considered a poxvirus (Postlethwaite, 1970) and recent chemical studies support this view (Pirie 1971). However, La Placa, Portolani & Rosa (1967) were unable to demonstrate non-genetic reactivation of heat-inactivated vaccinia virus with molluscum virus in human amnion cells. Since this might have resulted from failure of molluscum virus to adsorb to or to penetrate the cells (Burnett & Neva, 1966; Burnett & Sutton, 1968) or from the rapid development of virus interference, further studies seemed desirable with control of these variables. This report describes studies using mouse embryo cells, in which molluscum virus induces interferon-mediated heterologous interference, and mouse L cells in which it does not (Postlethwaite & Lee, 1970). Monkey pox virus was used as a control reactivating agent since, in preliminary experiments in both cells, it showed markedly impaired plaque production compared with vaccinia virus.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error