1887

Abstract

SUMMARY

The structural antigen Band II was present in cells infected with either type 1 or type 2 herpes simplex virus. Antiserum to Band II neutralized the infectivity of both virus types. General antisera to either type exhibited type specific neutralizing activity after absorption with heterologous antigen. Absorption of the antisera with Band II antigen from cells infected with either type 1 or type 2 virus also abolished the type common but not the type specific neutralizing activity. Fractions obtained by preparative polyacrylamide gel electrophoresis have been examined in serum blocking tests. The results suggest that particles of herpes simplex virus possess at least two type specific antigens and one type common antigen (Band II); interaction of any of these with the corresponding antibody causes loss of virus infectivity.

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1973-05-01
2022-01-20
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References

  1. Dubbs D. R., Kit S. 1964; Mutant strains of herpes simplex deficient in thymidine kinase-inducing ability. Virology 22:493–502
    [Google Scholar]
  2. Dulbecco R., Vogt M. 1954; Plaque formation and isolation of pure lines with poliomyelitis viruses. Journal of Experimental Medicine 99:167–82
    [Google Scholar]
  3. Geder L., Skinner G. R. B. 1971; Differentiation between type 1 and type 2 strains of herpes simplex virus by an indirect immunofluorecent technique. Journal of General Virology 12:179–182
    [Google Scholar]
  4. Halliburton I. W. 1972 In Oncogenesis and Herpes Viruses Edited by Biggs P. M., De-The G., Payne L. N. Lyons: IARC;
    [Google Scholar]
  5. Nahmias A. J., Del Buono I., Schneweis K. E., Gordon D. E., Thies D. 1971; Type-specific surface antigens of cells infected with herpes simplex virus (1 and 2). Proceedings of the Society for Experimental Biology and Medicine 138:21–27
    [Google Scholar]
  6. Nahmias A. J., Josey W. W., Naib Z. M., Luce C. F., Duffey A. 1970; Antibodies to herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. American Journal of Epidemiology 91:539–546
    [Google Scholar]
  7. Pauls F. P., Dowdle W. R. 1967; A serologic study of herpesvirus hominis strains by microneutralization tests. Journal of Immunology 98:941–947
    [Google Scholar]
  8. Pereira H. G., Laver W. G. 1970; Comparison of adenovirus types 2 and 5 hexons by immunological and biochemical techniques. Journal of General Virology 9:163–167
    [Google Scholar]
  9. Petterson U. 1971; Structural proteins of adenoviruses. VI. On the antigenic determinants of the hexon. Virology 43:123–136
    [Google Scholar]
  10. Plummer G. 1964; Serological comparison of the herpes viruses. British Journal of Experimental Pathology 45:I35–141
    [Google Scholar]
  11. Rawls W. E., Laurel D., Melnick J. L., Glicksman J. M., Kaufman R. H. 1968; A Search for viruses in smegma, premalignant and early malignant cervical tissues. The isolation of herpesviruses with distinct antigenic properties. American Journal of Epidemiology 87:647–655
    [Google Scholar]
  12. Roizman B. 1969; The herpesviruses - a biochemical definition of the group. Current Topics in Microbiology and Immunology 49:1–79
    [Google Scholar]
  13. Rowlands D. J., Sangar D. V., Brown F. 1971; Relationship of the antigenic structure of foot-and-mouth disease virus to the process of infection. Journal of General Virology 13:85–93
    [Google Scholar]
  14. Russell W. C. 1962; A sensitive and precise plaque assay for herpes virus. Nature, London 195:1028–029
    [Google Scholar]
  15. Schneweis K. E., Nahmias A. J. 1971; Antigens of herpes simplex virus type 1and 2 -immunodiffusion and inhibition passive haemagglutination studies. Zeitschrift für Immunitatsforschung und experimentelle Therapie 141:471–487
    [Google Scholar]
  16. Skinner G. R. B., Thouless M. E., Jordan J. A. 1971; Antibodies to type 1 and type 2 herpes virus in women with abnormal cervical cytology. Journal of Obstetrics and Gynaecology of the British Commonwealth 78:1031–1038
    [Google Scholar]
  17. Spring S. B., Roizman B. 1968; Differentiation of infectious virus derived from nucleus and cytoplasm with respect to stability and site. Journal of Virology 2:979–985
    [Google Scholar]
  18. Stein S., Todd P., Mahoney J. 1970; Infectivity of herpes simplex particles with and without envelopes. Canadian Journal of Microbiology 16:953–957
    [Google Scholar]
  19. Watson D. H. 1969; The separation of herpes virus specific antigens by polyacrylamide gel electrophoresis. Journal of General Virology 4:151–161
    [Google Scholar]
  20. Watson D. H., Shedden W. I. H., Elliot A., Tetsuka T., Wildy P., Bourgaux-Ramoisy D., Gold E. 1966; Virus specific antigens in mammalian cells infected with herpes simplex virus. Immunology n:399–408
    [Google Scholar]
  21. Watson D. H., Wildy P. 1969; The preparation of ‘monoprecipitin’ antisera to herpes virus specific antigens. Journal of General Virology 4:163–168
    [Google Scholar]
  22. Watson D. H., Wildy P., Russell W. C. 1964; Quantitative electron microscope studies on the growth of herpes virus using the techniques of negative staining and ultramicrotomy. Virology 24:523–538
    [Google Scholar]
  23. Webster R. G., Laver W. G. 1971; Antigenic variation in influenza virus. Biology and chemistry. Progress in Medical Virology 13:271–338
    [Google Scholar]
  24. Wilcox W. C., Ginsberg H. S. 1963; Production of specific neutralizing antibody with soluble antigens of type 5 adenovirus. Proceedings of the Society for Experimental Biology and Medicine 11437–42
    [Google Scholar]
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