The structural antigen Band II was present in cells infected with either type 1 or type 2 herpes simplex virus. Antiserum to Band II neutralized the infectivity of both virus types. General antisera to either type exhibited type specific neutralizing activity after absorption with heterologous antigen. Absorption of the antisera with Band II antigen from cells infected with either type 1 or type 2 virus also abolished the type common but not the type specific neutralizing activity. Fractions obtained by preparative polyacrylamide gel electrophoresis have been examined in serum blocking tests. The results suggest that particles of herpes simplex virus possess at least two type specific antigens and one type common antigen (Band II); interaction of any of these with the corresponding antibody causes loss of virus infectivity.


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