1887

Abstract

SUMMARY

The developmental sequence and subsequent release of the herpes simplex virus have been extensively studied by many investigators. Results by Morgan (1959), Shipkey (1967), Nii, Morgan & Rose (1968) have clearly shown that the naked nucleocapsids first appear in the nucleus of infected cells. Envelopment of the nucleocapsids occurred most frequently at the inner lamellae of the nuclear membrane and to a lesser extent at the membrane of cytoplasmic vacuoles (Nii 1968). However, the mechanism of virus release is still controversial. Epstein (1962) described virus budding at the cell surface while Morgan (1959) believed that viruses were released by the process of ‘reverse phagocytosis’. Recently, Schwartz & Roizman (1969) demonstrated the presence of cytoplasmic tubules which transported the enveloped nucleocapsids from perinuclear cisternae into the extracellular fluid. The entry of the infectious bovine rhinotracheitis (IBR) virus into the susceptible host cell has been previously reported (Zee & Talens, 1971).

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/content/journal/jgv/10.1099/0022-1317-17-3-333
1972-12-01
2022-01-18
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References

  1. Epstein M. A. 1962; Observations on the mode of release of herpesvirus from infected FleLa cells. Journal of Cell Biology 12:589–597
    [Google Scholar]
  2. Morgan C., Rose H. M., Holden M., Jones E. P. 1959; Electron microscopic observations on the development of herpes simplex virus. Journal of Experimental Medicine 110:643–656
    [Google Scholar]
  3. Nii S., Morgan C., Rose H. M. 1968; Electron microscopy of herpes simplex virus. II. Sequence of development. Journal of Virology 2:517–536
    [Google Scholar]
  4. Schwartz J., Roizman B. 1969; Concerning the egress of herpes simplex virus from infected cells: electron and light microscope observations. Virology 38:42–49
    [Google Scholar]
  5. Shipkey F. H., Erlandson R. A., Bailey R. B., Babcock V. I., Southam C. M. 1967; Virus biographies. II. Growth of herpes simplex virus in tissue culture. Experimental and Molecular Pathology 6:39–67
    [Google Scholar]
  6. Spear P. G., Keller J. M., Roizman B. 1970; Proteins specified by herpes simplex virus. II. Viral glycoproteins associated with cellular membranes. Journal of Virology 5:123–131
    [Google Scholar]
  7. Zee Y. C., Talens L. 1971; Entry of infectious bovine rhinotracheitis virus into cells. Journal of General Virology 11:59–63
    [Google Scholar]
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