High concentrations of interfering component added to BHK cells infected with the Indiana strain of vesicular stomatitis virus (VSV) inhibited the synthesis of virus and interfering component. The inhibition was at an early stage in virus replication. Lower concentrations of interfering component led to the formation of interfering component and depression of virus synthesis. When virus replication was depressed with interfering component prepared from a second strain of VSV (Brazil strain) the RNA of the Brazil interfering component was also replicated at the expense of the Indiana virus. The proteins of the progeny interfering component particles were of the Indiana virus type. It is proposed that interference can take place at different stages during infection, depending upon the amount of interfering component present.


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