Double-stranded RNA has been widely regarded as the inducer of interferon formation, both in virus-infected cells and in cells treated with synthetic polynucleotides (Colby, 1971). It is not difficult to see how infection with RNA viruses may lead to the formation of double-stranded RNA, but how do DNA viruses induce interferon formation? Colby & Duesberg (1969) have isolated a double-stranded RNA from chick cells infected with vaccinia virus, and shown that this double-stranded RNA induced interference against a virus challenge. However, they did not measure interferon production, either by virus infected cells or by the cells treated with double-stranded RNA, and since were found that chick cells infected by vaccinia virus did not produce interferon, there was some doubt about their explanation.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error