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A strain of foot-and-mouth disease virus (O1 bfs 1860) was found to be comparatively stable in aerosols at relative humidities above 55%: the inactivation rate was greater at lower relative humidities.
Virus precipitated with ammonium sulphate or methanol was considerably more unstable than untreated virus at relative humidities below 55%: this instability was not due to residual precipitant not removed by dialysis. Virus precipitated by polyethylene glycol or centrifuged at high speed was as stable as untreated virus. Possible reasons for the instability of virus precipitated by ammonium sulphate or methanol are discussed.
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