The inactivation of bacteriophages and myxoviruses by oxidized spermine, acrolein and glutaraldehyde has been studied. Oxidized spermine inactivated T5 and not T2 coliphages, while acrolein was more effective against T-even phages. Myxoviruses also differed in their sensitivity to the various aldehydes. This was determined by plaque counting or by assaying the haemagglutination activity after propagation in embryonated eggs.

High-molecular (condensation?) products, which were formed when spermine was oxidized for several hours by small quantities of enzyme also inactivated viruses.

These experiments stress the uniqueness of oxidized spermine as a virucidal agent, and do not support the hypothesis that its antivirus activity is due to the formation of acrolein as a spontaneous degradation product.


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