1887

Abstract

Recent experiments have indicated that the mol.wt. of the RNA of group A arboviruses is 3.5 to 5 × 10 (Cartwright & Burke, 1970; Strauss, 1969; Dobos & Faulkner, 1970). Denaturation of the 42s arbovirus genome by heat, dimethyl sulphoxide (DMSO) or 8 -urea resulted in: (i) the reduction of sedimentation coefficient to 26s, (ii) loss of infectivity, (iii) increased electrophoretic mobility in polyacrylamide gels indicating a reduction in mol.wt. to approximately 1.7 × 10 (Sreevalsan 1968; Sprecher-Goldberger, 1967; Dobos & Faulkner, 1969; Cartwright & Burke, 1970; Dobos & Faulkner, 1970). It appears that the arbovirus genome is not a single continuous polynucleotide chain but may consist of fragments which upon denaturation separate into pieces of mol.wt. 1.7 × 10 (Cartwright & Burke, 1970; Dobos & Faulkner, 1970).

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-10-1-103
1971-01-01
2019-10-14
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-10-1-103
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error