Recent experiments have indicated that the mol.wt. of the RNA of group A arboviruses is 3.5 to 5 × 10 (Cartwright & Burke, 1970; Strauss, 1969; Dobos & Faulkner, 1970). Denaturation of the 42s arbovirus genome by heat, dimethyl sulphoxide (DMSO) or 8 -urea resulted in: (i) the reduction of sedimentation coefficient to 26s, (ii) loss of infectivity, (iii) increased electrophoretic mobility in polyacrylamide gels indicating a reduction in mol.wt. to approximately 1.7 × 10 (Sreevalsan 1968; Sprecher-Goldberger, 1967; Dobos & Faulkner, 1969; Cartwright & Burke, 1970; Dobos & Faulkner, 1970). It appears that the arbovirus genome is not a single continuous polynucleotide chain but may consist of fragments which upon denaturation separate into pieces of mol.wt. 1.7 × 10 (Cartwright & Burke, 1970; Dobos & Faulkner, 1970).


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