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Mice in our scrapie-infected colony were found to have high levels of plasma lactic dehydrogenase activity. The cause of this appears to be contamination of mouse-passaged scrapie material with a plasma lactic dehydrogenase-elevating virus, similar to that normally found as a contaminant of transplantable mouse neoplasia. Mice inoculated with the Compton strain of scrapie virus or with sheep scrapie virus had normal plasma lactic dehydrogenase activities.
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