1887

Abstract

SUMMARY

Mice in our scrapie-infected colony were found to have high levels of plasma lactic dehydrogenase activity. The cause of this appears to be contamination of mouse-passaged scrapie material with a plasma lactic dehydrogenase-elevating virus, similar to that normally found as a contaminant of transplantable mouse neoplasia. Mice inoculated with the Compton strain of scrapie virus or with sheep scrapie virus had normal plasma lactic dehydrogenase activities.

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/content/journal/jgv/10.1099/0022-1317-1-4-449
1967-10-01
2021-10-20
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References

  1. Adams D. H., Bowman B. 1964; Studies on the properties of factors elevating the activity of mouse-plasma lactate dehydrogenase. Biochem. J 90:477
    [Google Scholar]
  2. Adams D. H., Rowson K. E. K., Salaman M. H. 1961; The effect of tumours, of leukaemia, and of some viruses associated with them, on the plasma lactic dehydrogenase activity of mice. Br. J. Cancer 15:860
    [Google Scholar]
  3. Alper T., Fiaig D. A., Clarke M. C. 1966; The exceptionally small size of the scrapie agent. Biochem. biophys. Res. Commun 22:278
    [Google Scholar]
  4. Berger L., Broida D. 1960; Colorimetric determination of lactic dehydrogenase at 400 to 550 mμ. Tech. Bull500 revised Sigma Chemical Co;
    [Google Scholar]
  5. Mould D. L., Smith W., Dawson A. McL. 1965; Centrifugation studies on the infectivities of cellular fractions derived from mouse brain infected with scrapie (‘Suffolk strain’). J. gen. Microbiol 40:71
    [Google Scholar]
  6. Notkins A. L. 1963; Studies of the properties and transmission of the lactic dehydrogenase agent. Proc. Am. Ass. Cancer Res 4:48
    [Google Scholar]
  7. Pattison I. H., Jones C. M. 1967; The possible nature of the transmission agent of scrapie. Vet. Rec 80:2
    [Google Scholar]
  8. Riley V. 1963; Evidence for a minute infectious entity. Proc. Am. Ass. Cancer Res 4:57
    [Google Scholar]
  9. Riley V., Loveless J. D., Fitzmaurice M. A. 1964; Comparison of a lactate-dehydrogenase elevating viruslike agent and Eperythrozoon coccoides . Proc. Soc. exp. Biol. Med 116:486
    [Google Scholar]
  10. Riley V., Lilly F., Huerto E., Bardell D. 1960; Transmissible agent associated with 26 types of experimental mouse neoplasms. Science, N.Y 132:545
    [Google Scholar]
  11. Zlotnik I. 1965; Observations on the experimental transmission of scrapie of various origins to laboratory animals. Natn. Inst, neurol. Dis. Monograph2237
    [Google Scholar]
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