1887

Abstract

Human herpes simplex virus (HSV)-1 infection is acquired in childhood and persists throughout a person’s lifetime. Here, we present two cases from India; one showing symptoms of postpartum haemorrhage with disseminated intravascular coagulation, and the second one showing signs of acute encephalitis syndrome. The aetiological agent in both cases was identified as HSV-1 using the PCR method. The next-generation sequencing method retrieved ~97 % of the viral genome from the isolates of the clinical samples. The phylogenetic analysis of the retrieved genomes revealed that they belong to clade II of HSV-1. This study identifies a few sequence variations in the glycoprotein region of HSV-1 during two different clinical manifestations. There are a couple of papers that analyse variations in the glycoprotein region of clinical samples. Further, this study also highlights the importance of considering HSV-1 during differential diagnosis when analysing the nosocomial infection.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Loading

Article metrics loading...

/content/journal/acmi/10.1099/acmi.0.000047
2019-08-01
2021-10-20
Loading full text...

Full text loading...

/deliver/fulltext/acmi/1/6/acmi000047.html?itemId=/content/journal/acmi/10.1099/acmi.0.000047&mimeType=html&fmt=ahah

References

  1. Laine RF, Albecka A, van de Linde S, Rees EJ, Crump CM et al. Structural analysis of herpes simplex virus by optical super-resolution imaging. Nat Commun 2015; 6:5980 [View Article]
    [Google Scholar]
  2. Kimberlin DW. Herpes simplex virus infections of the newborn. Semin Perinatol 2007; 31:19–25 [View Article]
    [Google Scholar]
  3. Lee R, Nair M. Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy. Obstet Med 2017; 10:58–60 [View Article]
    [Google Scholar]
  4. Simmons A. Clinical manifestations and treatment considerations of herpes simplex virus infection. J Infect Dis 2002; 186 Suppl 1:S71–S77 [View Article]
    [Google Scholar]
  5. James SH, Sheffield JS, Kimberlin DW. Mother-To-Child transmission of herpes simplex virus. J Pediatric Infect Dis Soc 2014; 3:S19–S23 [View Article]
    [Google Scholar]
  6. Bondre VP, Sankararaman V, Andhare V, Tupekar M, Sapkal GN. Genetic characterization of human herpesvirus type 1: full-length genome sequence of strain obtained from an encephalitis case from India. Indian J Med Res 2016; 144:750–760 [View Article]
    [Google Scholar]
  7. Brown JC. High G+C content of herpes simplex virus DNA: proposed role in protection against retrotransposon insertion. Open Biochem J 2007; 1:33–42 [View Article]
    [Google Scholar]
  8. Oda S, Arii J, Koyanagi N, Kato A, Kawaguchi Y. The interaction between herpes simplex virus 1 tegument proteins UL51 and UL14 and its role in virion morphogenesis. J Virol 2016; 90:8754–8767 [View Article]
    [Google Scholar]
  9. Reske A, Pollara G, Krummenacher C, Chain BM, Katz DR. Understanding HSV-1 entry glycoproteins. Rev Med Virol 2007; 17:205–215 [View Article]
    [Google Scholar]
  10. Jaggi U, Wang S, Tormanen K, Matundan H, Ljubimov AV et al. Role of herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) pathogenic CD8+ T cells in exacerbation of eye disease. Front Immunol 2018; 9:2895 [View Article]
    [Google Scholar]
  11. Sivadon V, Lebon P, Rozenberg F. Variations of HSV-1 glycoprotein B in human herpes simplex encephalitis. J Neurovirol 1998; 4:106–114 [View Article]
    [Google Scholar]
  12. Izumi KM, Stevens JG. Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene. J Exp Med 1990; 172:487–496 [View Article]
    [Google Scholar]
  13. Rozenberg F, Lebon P. Analysis of herpes simplex virus type 1 glycoprotein D nucleotide sequence in human herpes simplex encephalitis. J Neurovirol 1996; 2:289–295 [View Article]
    [Google Scholar]
  14. Arii J, Wang J, Morimoto T, Suenaga T, Akashi H et al. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis. J Virol 2010; 84:10773–10783 [View Article]
    [Google Scholar]
  15. Engel JP, Boyer EP, Goodman JL. Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype. Virology 1993; 192:112–120 [View Article]
    [Google Scholar]
  16. Sampath A, Maduro G, Schillinger JA. Infant deaths due to herpes simplex virus, congenital syphilis, and HIV in New York City. Pediatrics 2016; 137:e20152387 [View Article]
    [Google Scholar]
  17. Beig FK, Malik A, Rizvi M, Acharya D, Khare S. Etiology and clinico-epidemiological profile of acute viral encephalitis in children of Western Uttar Pradesh, India. Int J Infect Dis 2010; 14:e141–e146 [View Article]
    [Google Scholar]
  18. Modi A, Atam V, Jain N, Gutch M, Verma R. The etiological diagnosis and outcome in patients of acute febrile encephalopathy: a prospective observational study at tertiary care center. Neurol India 2012; 60:168–173 [View Article]
    [Google Scholar]
  19. Pfaff F, Groth M, Sauerbrei A, Zell R. Genotyping of herpes simplex virus type 1 by whole-genome sequencing. J Gen Virol 2016; 97:2732–2741 [View Article]
    [Google Scholar]
  20. Lan K, Luo M-H. Herpesviruses: epidemiology, pathogenesis and interventions. Virol Sin 2017; 32:347–348 [View Article]
    [Google Scholar]
  21. James SH, Whitley RJ. Treatment of herpes simplex virus infections in pediatric patients: current status and future needs. Clin Pharmacol Ther 2010; 88:720–724 [View Article]
    [Google Scholar]
  22. Allen UD, Robinson JL. Canadian Paediatric Society, Infectious Diseases and Immunization Committee Prevention and management of neonatal herpes simplex virus infections. Paediatr Child Health 2014; 19:201–206 [View Article]
    [Google Scholar]
  23. Jouan Y, Grammatico-Guillon L, Guillon A. Nosocomial herpes simplex encephalitis: does it really exist?. J Infect Public Health 2018; 11:142 [View Article]
    [Google Scholar]
  24. Young EJ, Chafizadeh E, Oliveira VL, Genta RM. Disseminated herpesvirus infection during pregnancy. Clin Infect Dis 1996; 22:51–58 [View Article]
    [Google Scholar]
  25. Arankalle VA, Lole KS, Deshmukh TM, Chobe LP, Gandhe SS. Evaluation of human (genotype 1) and swine (genotype 4)-ORF2-based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections. J Viral Hepat 2007; 14:435–445 [View Article]
    [Google Scholar]
  26. Liu J, Ochieng C, Wiersma S, Ströher U, Towner JS et al. Development of a taqman array card for acute-febrile-illness outbreak investigation and surveillance of emerging pathogens, including ebola virus. J Clin Microbiol 2016; 54:49–58 [View Article]
    [Google Scholar]
  27. Mourya DT, Yadav PD, Mehla R, Barde PV, Yergolkar PN et al. Diagnosis of Kyasanur forest disease by nested RT-PCR, real-time RT-PCR and IgM capture ELISA. J Virol Methods 2012; 186:49–54 [View Article]
    [Google Scholar]
  28. Waggoner JJ, Gresh L, Mohamed-Hadley A, Ballesteros G, Davila MJV et al. Single-Reaction multiplex reverse transcription PCR for detection of Zika, Chikungunya, and dengue viruses. Emerg Infect Dis 2016; 22:1295–1297 [View Article]
    [Google Scholar]
  29. Bondre VP, Jadi RS, Mishra AC, Yergolkar PN, Arankalle VA. West Nile virus isolates from India: evidence for a distinct genetic lineage. J Gen Virol 2007; 88:875–884 [View Article]
    [Google Scholar]
  30. Gurav YK, Tandale BV, Jadi RS, Gunjikar RS, Tikute SS et al. Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007. Indian J Med Res 2010; 132:395–399
    [Google Scholar]
  31. Sapkal GN, Wairagkar NS, Ayachit VM, Bondre VP, Gore MM. Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection. Am J Trop Med Hyg 2007; 77:1139–1145 [View Article]
    [Google Scholar]
  32. Weidmann M, Meyer-König U, Hufert FT. Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR. J Clin Microbiol 2003; 41:1565–1568 [View Article]
    [Google Scholar]
  33. Yadav P, Sarkale P, Patil D, Shete A, Kokate P et al. Isolation of Tioman virus from Pteropus giganteus bat in north-east region of India. Infect Genet Evol 2016; 45:224–229 [View Article]
    [Google Scholar]
  34. Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 2016; 33:1870–1874 [View Article]
    [Google Scholar]
  35. Martin DP, Murrell B, Golden M, Khoosal A, Muhire B. RDP4: detection and analysis of recombination patterns in virus genomes. Virus Evol 2015; 1: [View Article]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.0.000047
Loading
/content/journal/acmi/10.1099/acmi.0.000047
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error