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Volume 1, Issue 6

Identification and phylogenetic analysis of herpes simplex virus-1 from clinical isolates in India Open Access

Abstract

Human herpes simplex virus (HSV)-1 infection is acquired in childhood and persists throughout a person’s lifetime. Here, we present two cases from India; one showing symptoms of postpartum haemorrhage with disseminated intravascular coagulation, and the second one showing signs of acute encephalitis syndrome. The aetiological agent in both cases was identified as HSV-1 using the PCR method. The next-generation sequencing method retrieved ~97 % of the viral genome from the isolates of the clinical samples. The phylogenetic analysis of the retrieved genomes revealed that they belong to clade II of HSV-1. This study identifies a few sequence variations in the glycoprotein region of HSV-1 during two different clinical manifestations. There are a couple of papers that analyse variations in the glycoprotein region of clinical samples. Further, this study also highlights the importance of considering HSV-1 during differential diagnosis when analysing the nosocomial infection.

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  • Accepted:
  • Published Online:
Keyword(s): clade II , glycoproteins , Herpes Simplex Virus-1 and Next-generation sequencing
© 2019 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2019-08-01
2024-05-18
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Identification and phylogenetic analysis of herpes simplex virus-1 from clinical isolates in India
Access Microbiology 1, e000047 (2019); https://doi.org/10.1099/acmi.0.000047
/content/journal/acmi/10.1099/acmi.0.000047
/content/journal/acmi/10.1099/acmi.0.000047
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