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Microbial Genomics logo Microbial Genomics

Volume 7, Issue 8

Association between metabolic status and gut microbiome in obese populations Open Access

Abstract

Despite that obesity is associated with many metabolic diseases, a significant proportion (10–30 %) of obese individuals is recognized as ‘metabolically healthy obeses’ (MHOs). The aim of the current study is to characterize the gut microbiome for MHOs as compared to ‘metabolically unhealthy obeses’ (MUOs). We compared the gut microbiome of 172 MHO and 138 MUO individuals from Chongqing (China) (inclined to eat red meat and food with a spicy taste), and performed validation with selected biomarkers in 40 MHOs and 33 MUOs from Quanzhou (China) (inclined to eat seafood and food with a light/bland taste). The genera , and had increased abundance in both Chongqing and Quanzhou MHOs. We also observed different microbial functions in MUOs compared to MHOs, including an increased abundance of genes associated with glycan biosynthesis and metabolism. In addition, the microbial gene markers identified from the Chongqing cohort bear a moderate accuracy [AUC (area under the operating characteristic curve)=0.69] for classifying MHOs distinct from MUOs in the Quanzhou cohort. These findings indicate that gut microbiome is significantly distinct between MHOs and MUOs, implicating the potential of the gut microbiome in stratification and refined management of obesity.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): clinical indicators , gut microbiome , metabolic abnormality , obesity and two cohorts
Funding
This study was supported by the:
  • Sanming Project of Medicine in Shenzhen (Award SZSM202011016)
    • Principle Award Recipient: NotApplicable
  • National Key Clinical Specialty Discipline Construction Program of China (Award SZXK027)
    • Principle Award Recipient: NotApplicable
  • Shenzhen High-level Hospital Construction Fund (Award YBH2019-260)
    • Principle Award Recipient: NotApplicable
  • Military Healthcare Programs (Award 16BJZ40)
    • Principle Award Recipient: QiangZeng
  • Military Healthcare Programs (Award 15BJZ48)
    • Principle Award Recipient: QiangZeng
  • Natural Science Foundation of China (Award 81561128020)
    • Principle Award Recipient: QiangZeng
  • Natural Science Foundation of China (Award 81872920)
    • Principle Award Recipient: QiangZeng
  • Natural Science Foundation of China (Award 81602854)
    • Principle Award Recipient: QiangZeng
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License.
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2021-08-06
2025-01-24
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Association between metabolic status and gut microbiome in obese populations
M Gen 7, 000639 (2021); https://doi.org/10.1099/mgen.0.000639
/content/journal/mgen/10.1099/mgen.0.000639
/content/journal/mgen/10.1099/mgen.0.000639
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