1887

Abstract

Infection with the species complex represents an emerging problem in human and veterinary medicine with systemic mycoses presenting with significant clinical complications and being a cause of death.

In this report, a case of systemic infection discovered in a 3-year-old male neutered, German shepherd cross dog is described together with the clinical presentation, the course of the disease and diagnosis. This report describes the first case of veterinary mycosis due to in Europe and the first case in humans or animals in the UK.

Although seemingly rare, species complex infection should be a differential diagnosis for dogs, especially German shepherds with the described presenting signs, and radiographic and ultrasonographic findings.

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2017-10-16
2024-05-10
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References

  1. Ferrer C, Colom F, Frasés S, Mulet E, Abad JL et al. Detection and identification of fungal pathogens by PCR and by ITS2 and 5.8S ribosomal DNA typing in ocular infections. J Clin Microbiol 2001; 39:2873–2879 [View Article][PubMed]
    [Google Scholar]
  2. Irinyi L, Lackner M, de Hoog GS, Meyer W. DNA barcoding of fungi causing infections in humans and animals. Fungal Biol 2016; 120:125–136 [View Article][PubMed]
    [Google Scholar]
  3. Houbraken J, Spierenburg H, Frisvad JC. Rasamsonia, a new genus comprising thermotolerant and thermophilic Talaromyces and Geosmithia species. Antonie van Leeuwenhoek 2012; 101:403–421 [View Article][PubMed]
    [Google Scholar]
  4. Hong G, White M, Lechtzin N, West NE, Avery R et al. Fatal disseminated Rasamsonia infection in cystic fibrosis post-lung transplantation. J Cyst Fibros 2017; 16:e3-e7 [View Article][PubMed]
    [Google Scholar]
  5. Doyon JB, Sutton DA, Theodore P, Dhillon G, Jones KD et al. Rasamsonia argillacea pulmonary and aortic graft infection in an immune-competent patient. J Clin Microbiol 2013; 51:719–722 [View Article][PubMed]
    [Google Scholar]
  6. Giraud S, Pihet M, Razafimandimby B, Carrère J, Degand N et al. Geosmithia argillacea: an emerging pathogen in patients with cystic fibrosis. J Clin Microbiol 2010; 48:2381–2386 [View Article][PubMed]
    [Google Scholar]
  7. Ishiwada N, Takeshita K, Yaguchi T, Nagasawa K, Takeuchi N et al. The first case of invasive mixed-mold infections due to Emericella nidulans var. echinulata and Rasamsonia piperina in a patient with chronic Granulomatous disease. Mycopathologia 2016; 181:305–309 [View Article][PubMed]
    [Google Scholar]
  8. Matos T, Cerar T, Praprotnik M, Krivec U, Pirš M. First recovery of Rasamsonia argillacea species complex isolated in adolescent patient with cystic fibrosis in Slovenia–case report and review of literature. Mycoses 2015; 58:506–510 [View Article][PubMed]
    [Google Scholar]
  9. Grant DC, Sutton DA, Sandberg CA, Tyler RD, Thompson EH et al. Disseminated Geosmithia argillacea infection in a German Shepherd dog. Med Mycol 2009; 47:221–226 [View Article][PubMed]
    [Google Scholar]
  10. Salgüero R, Borman AM, Herrtage M, Benchekroun G, Abbondati E et al. Rasamsonia argillacea mycosis in a dog: first case in Europe. Vet Rec 2013; 172:581 [View Article][PubMed]
    [Google Scholar]
  11. Houbraken J, Giraud S, Meijer M, Bertout S, Frisvad JC et al. Taxonomy and antifungal susceptibility of clinically important Rasamsonia species. J Clin Microbiol 2013; 51:22–30 [View Article][PubMed]
    [Google Scholar]
  12. Schultz RM, Johnson EG, Wisner ER, Brown NA, Byrne BA et al. Clinicopathologic and diagnostic imaging characteristics of systemic aspergillosis in 30 dogs. J Vet Intern Med 2008; 22:851–859 [View Article][PubMed]
    [Google Scholar]
  13. Geffré A, Concordet D, Braun JP, Trumel C. Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel. Vet Clin Pathol 2011; 40:107–112 [View Article][PubMed]
    [Google Scholar]
  14. Robinson WF, Connole MD, King TJ, Pitt JI, Moss SM. Systemic mycosis due to Aspergillus deflectus in a dog. Aust Vet J 2000; 78:600–602 [View Article][PubMed]
    [Google Scholar]
  15. Walker JT, Frazho JK, Randell SC. A novel case of canine disseminated aspergillosis following mating. Can Vet J 2012; 53:190–192[PubMed]
    [Google Scholar]
  16. Zhang S, Corapi W, Quist E, Griffin S, Zhang M et al. Aspergillus versicolor, a new causative agent of canine disseminated aspergillosis. J Clin Microbiol 2012; 50:187–191 [View Article][PubMed]
    [Google Scholar]
  17. Day MJ, Eger CE, Shaw SE, Penhale WJ. Immunologic study of systemic aspergillosis in German shepherd dogs. Vet Immunol Immunopathol 1985; 9:335–347 [View Article][PubMed]
    [Google Scholar]
  18. Day MJ, Penhale WJ. An immunohistochemical study of canine disseminated aspergillosis. Aust Vet J 1991; 68:383–386 [View Article][PubMed]
    [Google Scholar]
  19. Day MJ, Penhale WJ. Humoral immunity in disseminated Aspergillus terreus infection in the dog. Vet Microbiol 1988; 16:283–294 [View Article][PubMed]
    [Google Scholar]
  20. Day MJ, Penhale WJ, Eger CE, Shaw SE, Kabay MJ et al. Disseminated aspergillosis in dogs. Aust Vet J 1986; 63:55–59 [View Article][PubMed]
    [Google Scholar]
  21. Stephen J, Ettinger ECF. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat, 5th ed. Philadelphia: W.B. Saunders Co; 2000
    [Google Scholar]
  22. Steinmann J, Dittmer S, Houbraken J, Buer J, Rath PM. In vitro activity of isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother 2016; 60:6890–6891 [View Article][PubMed]
    [Google Scholar]
  23. Steinmann J, Giraud S, Schmidt D, Sedlacek L, Hamprecht A et al. Validation of a novel real-time PCR for detecting Rasamsonia argillacea species complex in respiratory secretions from cystic fibrosis patients. New Microbes New Infect 2014; 2:72–78 [View Article][PubMed]
    [Google Scholar]
  24. Valentin T, Neumeister P, Pichler M, Rohn A, Koidl C et al. Disseminated Geosmithia argillacea infection in a patient with gastrointestinal GvHD. Bone Marrow Transplant 2012; 47:734–736 [View Article][PubMed]
    [Google Scholar]
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