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JMM Case Reports

Volume 3, Issue 5

Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy Open Access

Abstract

Introduction:

Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection.

Case presentation:

H. fennelliae bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for Helicobacter cinaedi bacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that the H. fennelliae bacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD.

Conclusion:

Our observations indicate that clinicians should be aware of possible recurrent H. fennelliae bacteraemia, which could be effectively prevented by SDD with kanamycin.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Helicobacter fennelliae , recurrent bacteremia, lung cancer, chemotherapy and selective digestive decontamination, kanamycin
© 2016 The Authors.
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2016-10-01
2019-10-16
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References

  1. Burnens A. P., Stanley J., Schaad U. B., Nicolet J..( 1993;). Novel campylobacter-like organism resembling Helicobacter fennelliae isolated from a boy with gastroenteritis and from dogs. . J Clin Microbiol 31: 1916––1917.[PubMed]
    [Google Scholar]
  2. Hewitt W. L., Finegold S. M..( 1958;). Laboratory studies with kanamycin. . Ann N Y Acad 76: 122––128.[CrossRef]
    [Google Scholar]
  3. Hsueh P. R., Teng L. J., Hung C. C., Chen Y. C., Yang P. C., Ho S. W., Luh K. T..( 1999;). Septic shock due to Helicobacter fennelliae in a non-human immunodeficiency virus-infected heterosexual patient. . J Clin Microbiol 37: 2084––2086.[PubMed]
    [Google Scholar]
  4. Imafuku A., Araoka H., Tanaka K., Marui Y., Sawa N., Ubara Y., Takaichi K., Ishii Y., Tomikawa S..( 2016;). Helicobacter cinaedi bacteremia in four renal transplant patients: clinical features and an important suggestion regarding the route of infection. . Transpl Infect Dis 18: 132––136. [CrossRef] [PubMed]
    [Google Scholar]
  5. Kawamura Y., Tomida J., Miyoshi-Akiyama T., Okamoto T., Narita M., Hashimoto K., Cnockaert M., Vandamme P., Morita Y. et al.( 2016;). Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines. . Syst Appl Microbiol 39: 307––312. [CrossRef] [PubMed]
    [Google Scholar]
  6. Kemper C. A., Mickelsen P., Morton A., Walton B., Deresinski S. C..( 1993;). Helicobacter (Campylobacter) fennelliae-like organisms as an important but occult cause of bacteraemia in a patient with AIDS. . J Infect 26: 97––101. [CrossRef] [PubMed]
    [Google Scholar]
  7. Kiehlbauch J. A., Tauxe R. V., Baker C. N., Wachsmuth I. K..( 1994;). Helicobacter cinaedi-associated bacteremia and cellulitis in immunocompromised patients. . Ann Intern Med 121: 90––93. [CrossRef] [PubMed]
    [Google Scholar]
  8. Kiehlbauch J. A., Brenner D. J., Cameron D. N., Steigerwalt A. G., Makowski J. M., Baker C. N., Patton C. M., Wachsmuth I. K..( 1995;). Genotypic and phenotypic characterization of Helicobacter cinaedi and Helicobacter fennelliae strains isolated from humans and animals. . J Clin Microbiol 33: 2940––2947.[PubMed]
    [Google Scholar]
  9. Kikuchi H., Asako K., Tansho S., Ueda T., Koshio O., Ubagai T., Asahara M., Kawakami S., Ono Y..( 2012;). Recurrent Helicobacter cinaedi cellulitis and bacteremia in a patient with systemic lupus erythematosus. . Intern Med 51: 3185––3188. [CrossRef] [PubMed]
    [Google Scholar]
  10. Mammen M. P., Aronson N. E., Edenfield W. J., Endy T. P..( 1995;). Recurrent Helicobacter cinaedi bacteremia in a patient infected with human immunodeficiency virus: case report. . Clin Infect Dis 21: 1055–– 1056. [CrossRef] [PubMed]
    [Google Scholar]
  11. Matsumoto T., Goto M., Murakami H., Tanaka T., Nishiyama H., Ono E., Okada C., Sawabe E., Yagoshi M. et al.( 2007;). Multicenter study to evaluate bloodstream infection by Helicobacter cinaedi in Japan. . J Clin Microbiol 45: 2853––2857. [CrossRef] [PubMed]
    [Google Scholar]
  12. Mégraud F., Lehours P..( 2007;). Helicobacter pylori detection and antimicrobial susceptibility testing. . Clin Microbiol Rev 20: 280––322. [CrossRef] [PubMed]
    [Google Scholar]
  13. Ménard A., Buissonnière A., Prouzet-Mauléon V., Sifré E., Mégraud F..( 2016;). The GyrA encoded gene: a pertinent marker for the phylogenetic revision of Helicobacter genus. . Syst Appl Microbiol 39: 77––87. [CrossRef] [PubMed]
    [Google Scholar]
  14. Ng V. L., Hadley W. K., Fennell C. L., Flores B. M., Stamm W. E..( 1987;). Successive bacteremias with "C ampylobacter cinaedi" and "C ampylobacter fennelliae" in a bisexual male. . J Clin Microbiol 25: 2008––2009.[PubMed]
    [Google Scholar]
  15. Nishine H., Kasai S., Yoshikawa M., Otsuka Y., Tokuda H..( 2007;). [A case of recurrent Helicobacter cinaedi-associated bacteremia in a small cell lung cancer patient during chemotherapy]. . Nihon Kokyuki Gakkai Zasshi 45: 26––30 [in Japanese].[PubMed]
    [Google Scholar]
  16. Rimbara E., Mori S., Matsui M., Suzuki S., Wachino J., Kawamura Y., Shen Z., Fox J. G., Shibayama K..( 2012;). Molecular epidemiologic analysis and antimicrobial resistance of Helicobacter cinaedi isolated from seven hospitals in Japan. . J Clin Microbiol 50: 2553––2560. [CrossRef] [PubMed]
    [Google Scholar]
  17. Rimbara E., Matsui M., Mori S., Suzuki S., Suzuki M., Kim H., Sekizuka T., Kuroda M., Shibayama K..( 2013a;). Draft genome sequence of Helicobacter fennelliae strain MRY12-0050, isolated from a bacteremia patient. . Genome Announc 1: e00512-13. [CrossRef]
    [Google Scholar]
  18. Rimbara E., Mori S., Kim H., Matsui M., Suzuki S., Takahashi S., Yamamoto S., Mukai M., Shibayama K..( 2013b;). Helicobacter cinaedi and Helicobacter fennelliae transmission in a hospital from 2008 to 2012. . J Clin Microbiol 51: 2439––2442. [CrossRef]
    [Google Scholar]
  19. Saito S., Tsukahara M., Ohkusu K., Kurai H..( 2016;). Helicobacter fennelliae bacteremia: three case reports and literature review. . Medicine 95: e3556. [CrossRef] [PubMed]
    [Google Scholar]
  20. Smuts H. E., Lastovica A. J..( 2011;). Molecular characterization of the 16S rRNA gene of Helicobacter fennelliae isolated from stools and blood cultures from paediatric patients in South Africa. . J Pathog 2011: 217376. [CrossRef] [PubMed]
    [Google Scholar]
  21. Stojanovska V., Sakkal S., Nurgali K..( 2015;). Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity. . Am J Physiol Gastrointest Liver Physiol 308: G223––G232. [CrossRef] [PubMed]
    [Google Scholar]
  22. Sullivan A. K., Nelson M. R., Walsh J., Gazzard B. G..( 1997;). Recurrent Helicobacter cinaedi cellulitis and bacteraemia in a patient with HIV Infection. . Int J STD AIDS 8: 59––60. [CrossRef] [PubMed]
    [Google Scholar]
  23. Tee W., Street A. C., Spelman D., Munckhof W., Mijch A..( 1996;). Helicobacter cinaedi bacteraemia: varied clinical manifestations in three homosexual males. . Scand J Infect Dis 28: 199––203. [CrossRef] [PubMed]
    [Google Scholar]
  24. Tomida J., Oumi A., Okamoto T., Morita Y., Okayama A., Misawa N., Hayashi T., Akaike T., Kawamura Y..( 2013;). Comparative evaluation of agar dilution and broth microdilution methods for antibiotic susceptibility testing of Helicobacter cinaedi. . Microbiol Immunol 57: 353––358. [CrossRef] [PubMed]
    [Google Scholar]
  25. Uçkay I., Garbino J., Dietrich P. Y., Ninet B., Rohner P., Jacomo V..( 2006;). Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature. . BMC Infect Dis 6: 86. [CrossRef] [PubMed]
    [Google Scholar]
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Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
JMM Case Rep 3, e005069 (2016); https://doi.org/10.1099/jmmcr.0.005069
/content/journal/jmmcr/10.1099/jmmcr.0.005069
/content/journal/jmmcr/10.1099/jmmcr.0.005069
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