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JMM Case Reports JMM Case Reports

Volume 3, Issue 5

Successful treatment of recurrent bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy Open Access

Abstract

Introduction:

is an enterohepatic species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for infection.

Case presentation:

bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for bacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that the bacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD.

Conclusion:

Our observations indicate that clinicians should be aware of possible recurrent bacteraemia, which could be effectively prevented by SDD with kanamycin.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Helicobacter fennelliae , recurrent bacteremia, lung cancer, chemotherapy and selective digestive decontamination, kanamycin
2016 The Authors.
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2016-09-01
2025-07-20
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References

  1. Burnens A. P., Stanley J., Schaad U. B., Nicolet J. 1993; Novel campylobacter-like organism resembling Helicobacter fennelliae isolated from a boy with gastroenteritis and from dogs. J Clin Microbiol 31:1916–1917[PubMed]
     [Google Scholar]
  2. Hewitt W. L., Finegold S. M. 1958; Laboratory studies with kanamycin. Ann N Y Acad 76:122–128 [CrossRef]
     [Google Scholar]
  3. Hsueh P. R., Teng L. J., Hung C. C., Chen Y. C., Yang P. C., Ho S. W., Luh K. T. 1999; Septic shock due to Helicobacter fennelliae in a non-human immunodeficiency virus-infected heterosexual patient. J Clin Microbiol 37:2084–2086[PubMed]
     [Google Scholar]
  4. Imafuku A., Araoka H., Tanaka K., Marui Y., Sawa N., Ubara Y., Takaichi K., Ishii Y., Tomikawa S. 2016; Helicobacter cinaedi bacteremia in four renal transplant patients: clinical features and an important suggestion regarding the route of infection. Transpl Infect Dis 18:132–136 [View Article][PubMed]
     [Google Scholar]
  5. Kawamura Y., Tomida J., Miyoshi-Akiyama T., Okamoto T., Narita M., Hashimoto K., Cnockaert M., Vandamme P., Morita Y. et al. 2016; Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines. Syst Appl Microbiol 39:307–312 [View Article][PubMed]
     [Google Scholar]
  6. Kemper C. A., Mickelsen P., Morton A., Walton B., Deresinski S. C. 1993; Helicobacter (Campylobacter) fennelliae-like organisms as an important but occult cause of bacteraemia in a patient with AIDS. J Infect 26:97–101 [View Article][PubMed]
     [Google Scholar]
  7. Kiehlbauch J. A., Tauxe R. V., Baker C. N., Wachsmuth I. K. 1994; Helicobacter cinaedi-associated bacteremia and cellulitis in immunocompromised patients. Ann Intern Med 121:90–93 [View Article][PubMed]
     [Google Scholar]
  8. Kiehlbauch J. A., Brenner D. J., Cameron D. N., Steigerwalt A. G., Makowski J. M., Baker C. N., Patton C. M., Wachsmuth I. K. 1995; Genotypic and phenotypic characterization of Helicobacter cinaedi and Helicobacter fennelliae strains isolated from humans and animals. J Clin Microbiol 33:2940–2947[PubMed]
     [Google Scholar]
  9. Kikuchi H., Asako K., Tansho S., Ueda T., Koshio O., Ubagai T., Asahara M., Kawakami S., Ono Y. 2012; Recurrent Helicobacter cinaedi cellulitis and bacteremia in a patient with systemic lupus erythematosus. Intern Med 51:3185–3188 [View Article][PubMed]
     [Google Scholar]
  10. Mammen M. P., Aronson N. E., Edenfield W. J., Endy T. P. 1995; Recurrent Helicobacter cinaedi bacteremia in a patient infected with human immunodeficiency virus: case report. Clin Infect Dis 21:1055–1056 [View Article][PubMed]
     [Google Scholar]
  11. Matsumoto T., Goto M., Murakami H., Tanaka T., Nishiyama H., Ono E., Okada C., Sawabe E., Yagoshi M. et al. 2007; Multicenter study to evaluate bloodstream infection by Helicobacter cinaedi in Japan. J Clin Microbiol 45:2853–2857 [View Article][PubMed]
     [Google Scholar]
  12. Mégraud F., Lehours P. 2007; Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev 20:280–322 [View Article][PubMed]
     [Google Scholar]
  13. Ménard A., Buissonnière A., Prouzet-Mauléon V., Sifré E., Mégraud F. 2016; The GyrA encoded gene: a pertinent marker for the phylogenetic revision of Helicobacter genus. Syst Appl Microbiol 39:77–87 [View Article][PubMed]
     [Google Scholar]
  14. Ng V. L., Hadley W. K., Fennell C. L., Flores B. M., Stamm W. E. 1987; Successive bacteremias with "C ampylobacter cinaedi" and "C ampylobacter fennelliae" in a bisexual male. J Clin Microbiol 25:2008–2009[PubMed]
     [Google Scholar]
  15. Nishine H., Kasai S., Yoshikawa M., Otsuka Y., Tokuda H. 2007; [A case of recurrent Helicobacter cinaedi-associated bacteremia in a small cell lung cancer patient during chemotherapy]. Nihon Kokyuki Gakkai Zasshi 45:26–30 [in Japanese][PubMed]
     [Google Scholar]
  16. Rimbara E., Mori S., Matsui M., Suzuki S., Wachino J., Kawamura Y., Shen Z., Fox J. G., Shibayama K. 2012; Molecular epidemiologic analysis and antimicrobial resistance of Helicobacter cinaedi isolated from seven hospitals in Japan. J Clin Microbiol 50:2553–2560 [View Article][PubMed]
     [Google Scholar]
  17. Rimbara E., Matsui M., Mori S., Suzuki S., Suzuki M., Kim H., Sekizuka T., Kuroda M., Shibayama K. 2013a; Draft genome sequence of Helicobacter fennelliae strain MRY12-0050, isolated from a bacteremia patient. Genome Announc 1:e00512-13 [View Article]
     [Google Scholar]
  18. Rimbara E., Mori S., Kim H., Matsui M., Suzuki S., Takahashi S., Yamamoto S., Mukai M., Shibayama K. 2013b; Helicobacter cinaedi and Helicobacter fennelliae transmission in a hospital from 2008 to 2012. J Clin Microbiol 51:2439–2442 [View Article]
     [Google Scholar]
  19. Saito S., Tsukahara M., Ohkusu K., Kurai H. 2016; Helicobacter fennelliae bacteremia: three case reports and literature review. Medicine 95:e3556 [View Article][PubMed]
     [Google Scholar]
  20. Smuts H. E., Lastovica A. J. 2011; Molecular characterization of the 16S rRNA gene of Helicobacter fennelliae isolated from stools and blood cultures from paediatric patients in South Africa. J Pathog 2011:217376 [View Article][PubMed]
     [Google Scholar]
  21. Stojanovska V., Sakkal S., Nurgali K. 2015; Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity. Am J Physiol Gastrointest Liver Physiol 308:G223–G232 [View Article][PubMed]
     [Google Scholar]
  22. Sullivan A. K., Nelson M. R., Walsh J., Gazzard B. G. 1997; Recurrent Helicobacter cinaedi cellulitis and bacteraemia in a patient with HIV Infection. Int J STD AIDS 8:59–60 [View Article][PubMed]
     [Google Scholar]
  23. Tee W., Street A. C., Spelman D., Munckhof W., Mijch A. 1996; Helicobacter cinaedi bacteraemia: varied clinical manifestations in three homosexual males. Scand J Infect Dis 28:199–203 [View Article][PubMed]
     [Google Scholar]
  24. Tomida J., Oumi A., Okamoto T., Morita Y., Okayama A., Misawa N., Hayashi T., Akaike T., Kawamura Y. 2013; Comparative evaluation of agar dilution and broth microdilution methods for antibiotic susceptibility testing of Helicobacter cinaedi . Microbiol Immunol 57:353–358 [View Article][PubMed]
     [Google Scholar]
  25. Uçkay I., Garbino J., Dietrich P. Y., Ninet B., Rohner P., Jacomo V. 2006; Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature. BMC Infect Dis 6:86 [View Article][PubMed]
     [Google Scholar]
/content/journal/jmmcr/10.1099/jmmcr.0.005069
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Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
JMM Case Rep 3, e005069 (2016); https://doi.org/10.1099/jmmcr.0.005069
/content/journal/jmmcr/10.1099/jmmcr.0.005069
/content/journal/jmmcr/10.1099/jmmcr.0.005069
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