1887

Abstract

Introduction

Elephant endotheliotropic herpesvirus-1 (EEHV-1) is one of the major causes of fatality in juvenile Asian elephants (). On occasions, other EEHV genotypes, i.e. EEHV-3, -4 and -5, have also been reported as the cause of Asian elephant deaths. In this case report we describe the investigation into a juvenile Asian elephant fatality in a European zoo.

Case Presentation:

A fatal case of haemorrhagic disease in a juvenile Asian elephant from a European zoo was diagnosed with co-infection of EEHV-1 and -4. EEHV-4 had a wider organ distribution and a higher viral load; both viruses presented the highest load in the mesenteric lymph nodes.

Conclusion:

Detection of EEHV-4 in this fatal case in Europe underlines the importance of inclusion of all known Asian EEHVs in routine blood monitoring to facilitate early therapeutic intervention.

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2016-04-02
2019-10-20
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References

  1. Ahmed A. . 2014; Immunopathology of CMV co-infection. MOJ Immunol 1: 00017 [CrossRef]
    [Google Scholar]
  2. Chapenko S. , Folkmane I. , Tomsone V. , Amerika D. , Rozentals R. , Murovska M. . 2000; Co-infection of two β-herpesviruses (CMV and HHV-7) as an increased risk factor for ‘CMV disease’ in patients undergoing renal transplantation. Clin Transplant 14: 486– 492 16861032 [CrossRef]
    [Google Scholar]
  3. Denk D. , Stidworthy M.F. , Redrobe S. , Latimer E. , Hayward G.S. , Cracknell J. , Claessens A. , Steinbach F. , McGowan S. , Dastjerdi A. . 2012; Fatal elephant endotheliotropic herpesvirus type 5 infection in a captive Asian elephant. Vet Rec 171: 380– 381 [CrossRef] [PubMed]
    [Google Scholar]
  4. Fillatre P. , Chevrier S. , Revest M. , Gacouin A. , Jouneau S. , Leroy H. , Robert-Gangneux F. , Minjolle S. , Le Tulzo Y. , Tattevin P. . 2013; Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia. Eur J Clin Microbiol Infect Dis 32: 189– 194 [CrossRef] [PubMed]
    [Google Scholar]
  5. Garner M.M. , Helmick K. , Ochsenreiter J. , Richman L.K. , Latimer E. , Wise A.G. , Maes R.K. , Kiupel M. , Nordhausen R.W. , other authors . 2009; Clinico-pathologic features of fatal disease attributed to new variants of endotheliotropic herpesviruses in two Asian elephants (Elephas maximus. Vet Pathol 46: 97– 104 [CrossRef] [PubMed]
    [Google Scholar]
  6. Hardman K. , Dastjerdi A. , Gurrala R. , Routh A. , Banks M. , Steinbach F. , Bouts T. . 2012; Detection of elephant endotheliotropic herpesvirus type 1 in asymptomatic elephants using TaqMan real-time PCR. Vet Rec 170: 205 [CrossRef] [PubMed]
    [Google Scholar]
  7. Latimer E. , Zong J.C. , Heaggans S.Y. , Richman L.K. , Hayward G.S. . 2011; Detection and evaluation of novel herpesviruses in routine and pathological samples from Asian and African elephants: identification of two new probosciviruses (EEHV5 and EEHV6) and two new gammaherpesviruses (EGHV3B and EGHV5). Vet Microbiol 147: 28– 41 [CrossRef] [PubMed]
    [Google Scholar]
  8. Ortega J. , Corpa J.M. , Orden J.A. , Blanco J. , Carbonell M.D. , Gerique A.C. , Latimer E. , Hayward G.S. , Roemmelt A. , other authors . 2015; Acute death associated with Citrobacter freundii infection in an African elephant (Loxodonta africana. J Vet Diagn Invest 27: 632– 636 [CrossRef] [PubMed]
    [Google Scholar]
  9. Reid C.E. , Martina B.E.E. , Schaftenaar W. , Osterhaus A.D.M.E. . 2008; Development of a recombinant protein based ELISA for the detection of EEHV: an improvement on the peptide based ELISA to increase sensitivity, specificity and reproducibility. In Proceedings of the International Elephant Conservation and Research Symposium 62: 24– 26
    [Google Scholar]
  10. Sripiboon S. , Tankaew P. , Lungka G. , Thitaram C. . 2013; The occurrence of elephant endotheliotropic herpesvirus in captive Asian elephants (Elephas maximus): first case of EEHV4 in Asia. J Zoo Wildl Med 44: 100– 104 [CrossRef] [PubMed]
    [Google Scholar]
  11. Stanton J.J. , Zong J.C. , Eng C. , Howard L. , Flanagan J. , Stevens M. , Schmitt D. , Wiedner E. , Graham D. , other authors . 2013; Kinetics of viral loads and genotypic analysis of elephant endotheliotropic herpesvirus-1 infection in captive Asian elephants (Elephas maximus. J Zoo Wildl Med 44: 42– 54 [CrossRef] [PubMed]
    [Google Scholar]
  12. Tang Y.W. , Espy M.J. , Persing D.H. , Smith T.F. . 1997; Molecular evidence and clinical significance of herpesvirus coinfection in the central nervous system. J Clin Microbiol 35: 2869– 2872 9350749
    [Google Scholar]
  13. van den Doel P.B. , Prieto V.R. , van Rossum-Fikkert S.E. , Schaftenaar W. , Latimer E. , Howard L. , Chapman S. , Masters N. , Osterhaus A.D. , other authors . 2015; A novel antigen capture ELISA for the specific detection of IgG antibodies to elephant endotheliotropic herpes virus. BMC Vet Res 11: 203 [CrossRef] [PubMed]
    [Google Scholar]
  14. Wilkie G.S. , Davison A.J. , Kerr K. , Stidworthy M.F. , Redrobe S. , Steinbach F. , Dastjerdi A. , Denk D. . 2014; First fatality associated with elephant endotheliotropic herpesvirus 5 in an Asian elephant: pathological findings and complete viral genome sequence. Sci Rep 4: 6299 [CrossRef] [PubMed]
    [Google Scholar]
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