1887

Abstract

Introduction:

Non‐typhoidal (NTS) are commonly implicated in causing bacteraemia in infants, the elderly and immunosuppressed individuals in sub‐Saharan African countries. However, NTS bacteraemia in otherwise healthy adults from India has been rarely reported. Here, we report a case of bacteraemia caused by serovar Choleraesuis ( Choleraesuis), isolated simultaneously from the blood and urine of an adult febrile patient from Kolkata, India.

Case Presentation:

A middle‐aged man was admitted to a private hospital in Kolkata with clinical suspicion of acute enteric fever on 25 October 2013. His blood report showed neutropenia and mild thrombocytopenia, with an elevated C‐reactive protein level. The Widal test was negative. Choleraesuis isolates were grown simultaneously by microbiological culture of blood and urine samples. The patient recovered without complications following antibiotic therapy. On further characterization, both of the Choleraesuis isolates showed identical antibiotic‐susceptibility patterns and virulence‐gene, plasmid and PFGE profiles, confirming their clonality (100% similarity).

Conclusion:

This is the first report of Choleraesuis bacteraemia associated with a human infection in India. The identification and reporting of uncommon serovars from various countries are important for understanding the global epidemiology of salmonellosis.

  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.003210
2014-09-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/1/3/jmmcr003210.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.003210&mimeType=html&fmt=ahah

References

  1. CDC( 2013). Standard operating procedure for PulseNet PFGE of Escherichia coli O157:H7, Escherichia coli non‐O157 (STEC), Salmonella serotypes, Shigella sonnei and Shigella flexneri. Atlanta, GA: Centers for Disease Control and Prevention;
    [Google Scholar]
  2. Chen P.L., Wu C.J., Chang C.M., Lee H.C., Lee N.Y., Shih H.I., Lee C.C., Ko N.Y., Wang L.R., Ko W.C. ( 2007). Extraintestinal focal infections in adults with Salmonella enterica serotype Choleraesuis bacteremia. J Microbiol Immunol Infect 40:240–247
    [Google Scholar]
  3. Chiu C.H., Su L.H., Chu C. ( 2004). Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment. Clin Microbiol Rev 17:311–322 [CrossRef]
    [Google Scholar]
  4. CLSI( 2012). Performance Standards for Antimicrobial Susceptibility Testing; M100‐S22. Wayne, PA: Clinical and Laboratory Standards Institute;
    [Google Scholar]
  5. Coburn B., Grassl G.A., Finlay B.B. ( 2007). Salmonella, the host and disease: a brief review. Immunol Cell Biol 85:112–118 [CrossRef]
    [Google Scholar]
  6. Dutta S., Das S., Mitra U., Jain P., Roy I., Ganguly S., Ray U., Dutta P., Paul D. ( 2014). Antimicrobial resistance, virulence profiles and molecular subtypes of Salmonella enterica serovars Typhi and Paratyphi A blood isolates from Kolkata, India during 2009–2013. PLoS One doi 10.1371/journal.pone.0101347
    [Google Scholar]
  7. Fadeel M.A., Crump J.A., Mahoney F.J., Nakhla I.A., Mansour A.M., Reyad B., El Melegi D., Sultan Y., Mintz E.D., Bibb W.F. ( 2004). Rapid diagnosis of typhoid fever by enzyme‐linked immunosorbent assay detection of Salmonella serotype Typhi antigens in urine. Am J Trop Med Hyg 70:323–328
    [Google Scholar]
  8. Gordon M.A., Graham S.M., Walsh A.L., Wilson L., Phiri A., Molyneux E., Zijlstra E.E., Heyderman R.S., Hart C.A., Molyneux M.E. ( 2008). Epidemics of invasive Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium infection associated with multidrug resistance among adults and children in Malawi. Clin Infect Dis 46:963–969 [CrossRef]
    [Google Scholar]
  9. Jean S.S., Wang J.Y., Hsueh P.R. ( 2006). Bacteremia caused by Salmonella enterica serotype Cholerasuis in Taiwan. J Microbiol Immunol Infect 39:358–365
    [Google Scholar]
  10. Kado C.I., Liu S.L. ( 1981). Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol 145:1365–1373
    [Google Scholar]
  11. Karthikeyan K., Thirunarayan M., Krishnan P. ( 2011). CTX‐M‐15 type ESBL producing Salmonella from a pediatric patient in Chennai, India. Indian J Med Res 134:487–489
    [Google Scholar]
  12. Kulwichit W., Chatsuwan T., Unhasuta C., Pulsrikarn C., Bangtrakulnonth A., Chongthaleong A. ( 2007). Drug‐resistant non‐typhoidal Salmonella bacteremia, Thailand. Emerg Infect Dis 13:501–502 [CrossRef]
    [Google Scholar]
  13. Kumar G., Pratap C.B., Mishra O.P., Kumar K., Nath G. ( 2012). Use of urine with nested PCR targeting the flagellin gene (fliC) for diagnosis of typhoid fever. J Clin Microbiol 50:1964–1967 [CrossRef]
    [Google Scholar]
  14. Menezes G.A., Khan M.A., Harish B.N., Parija S.C., Goessens W., Vidyalakshmi K., Baliga S., Hays J.P. ( 2010). Molecular characterization of antimicrobial resistance in non‐typhoidal salmonellae associated with systemic manifestations from India. J Med Micobiol 59:1477–1483 [CrossRef]
    [Google Scholar]
  15. Mtove G., Amos B., von Seidlein L., Hendriksen I., Mwambuli A., Kimera J., Mallahiyo R., Kim D.R., Ochiai R.L., Clemens J.D. other authors( 2010). Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies. PLoS One 5:e9244 [CrossRef]
    [Google Scholar]
  16. Muley V.A., Po l.S.S., Dohe V.B., Nagdawane R.P., Arjunwadkar V.P., Pandit D.P., Bharadwaj R.S. ( 2004). Neonatal outbreak of Salmonella Worthington in a general hospital. Indian J Med Microbiol 22:51–53
    [Google Scholar]
  17. Ochiai R.L., Acosta C.J., Danovaro‐Holliday M.C., Baiqing D., Bhattacharya S.K., Agtini M.D., Bhutta Z.A., Canh do G., Ali M. other authors( 2008). A study of typhoid fever in five Asian countries: disease burden and implications for control. Bull World Health Organ 86:260–268 [CrossRef]
    [Google Scholar]
  18. Patil A.B., Krishna B.V.S., Chandrasekher M.R. ( 2006). Neonatal sepsis caused by Salmonella enterica serovar Weltevreden. Southeast Asian J Trop Med Public Health 37:1175–1178
    [Google Scholar]
  19. Randhawa V.S., Mehta G., Das A., Chugh A., Aneja S. ( 2006). Rare serotype non‐typhoidal Salmonella sepsis. Ind J Pediatr 73:1039–1040 [CrossRef]
    [Google Scholar]
  20. Soto S.M., Rodríguez I., Rodicio M.R., Vila J., Mendoza M.C. ( 2006). Detection of virulence determinants in clinical strains of Salmonella enterica serovar Enteritidis and mapping on macrorestriction profiles. J Med Microbiol 55:365–373 [CrossRef]
    [Google Scholar]
  21. Su L.H., Teng W.S., Chen C.L., Lee H.Y., Li H.C., Wu T.L., Chiu C.H. ( 2011). Increasing ceftriaxone resistance in salmonellae, Taiwan. Emerg Infect Dis 17:1086–1090 [CrossRef]
    [Google Scholar]
  22. Villa L., García‐Fernández A., Fortini D., Carattoli A. ( 2010). Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants. J Antimicrob Chemother 65:2518–2529 [CrossRef]
    [Google Scholar]
  23. Wang J.Y., Hwang J.J., Hsu C.N., Lin L.C., Hsueh P.R. ( 2006). Bacteremia due to ciprofloxacin‐resistant Salmonella enterica serotype Cholerasuis in adult patients at a university hospital in Taiwan, 1996–2004. Epidemiol Infect 134:977–984 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.003210
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.003210
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error