Version 1: Whole Genome Sequencing Based Characterization of Streptomyces sp. 6(4): focus on natural products

We have sequenced the whole genome of Streptomyces sp. 6(4) isolated from tomato roots that presents antifungal activity against phytopathogenic fungi, mainly against Bipolaris sorokiniana . The genome has almost 7 Mb and 3,368 hypothetical proteins that were analyzed and characterized in Uniprot with emphasize in biological compounds. MLST analysis were performed in effort to characterize and identify this isolate, resulting in a new ST, classified as ST64. Phenetic and phylogenetic trees were constructed to investigate Streptomyces sp. 6(4) evolution and sequence similarity, and the isolate is a strain closer to Streptomyces prasinus and Streptomyces viridosporus . It is known that Streptomyces genera comprises a huge metabolism capacity with the presence of cryptic genes. These genes are usually present in clusters who are responsible for production of a high diversity of natural products, mainly antibiotics. In addition, 6(4) showed 11 biosynthetic gene cluster through antiSMASH, including 3 clusters PKS and NRPS type.