Trends in Coagulase negative Staphylococci (CoNS), England, 2010-2021

Karthik Paranthaman; Allegra Wilson; Neville Verlander; Graeme Rooney; Neil Macdonald; Olisaeloka Nsonwu; Russell Hope; Paul Fleming; James Hatcher; Enitan Ogundipe; Natasha Ratnaraja; Yu Wan; Bruno Pichon; Samantha J Westrop; Colin S Brown; Alicia Demirjian

doi:10.1099/acmi.0.000491.v1

Research Article

Open Access

Version 1: Trends in Coagulase negative Staphylococci (CoNS), England, 2010-2021

Karthik Paranthaman¹, Allegra Wilson², Neville Verlander³, Graeme Rooney⁴, Neil Macdonald⁵, Olisaeloka Nsonwu⁶, Russell Hope⁷, Paul Fleming⁸, James Hatcher⁹, Enitan Ogundipe¹⁰, Natasha Ratnaraja¹¹, Yu Wan¹², Bruno Pichon¹³, Samantha J Westrop¹⁴, Colin S Brown¹⁵ and Alicia Demirjian¹⁶
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Affiliations: ¹ Ukhsa: UK Health Security Agency, Nobel House, London ² U.K. Health Security Agency, London, UK ³ U.K. Health Security Agency, London, UK ⁴ U.K. Health Security Agency, London, UK ⁵ U.K. Health Security Agency, London, UK ⁶ U.K. Health Security Agency, London, UK ⁷ U.K. Health Security Agency, London, UK ⁸ Homerton Healthcare NHS Foundation Trust, London, UK Queen Mary University of London, London, UK ⁹ Great Ormond Street Hospital for Children, London, UK ¹⁰ Chelsea and Westminster NHS Foundation Trust, London, UK Imperial College London, London, UK ¹¹ University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK ¹² U.K. Health Security Agency, London, UK Nihr Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK ¹³ U.K. Health Security Agency, London, UK ¹⁴ U.K. Health Security Agency, London, UK ¹⁵ U.K. Health Security Agency, London, UK 8nihr Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK ¹⁶ U.K. Health Security Agency, London, UK Evelina London Children's Hospital, London, UK King’s College London, London, UK
*Correspondence: Karthik Paranthaman, [email protected]
Version Posted: 09 September 2022 https://doi.org/10.1099/acmi.0.000491.v1
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Abstract

Objective: To review the epidemiology of Coagulase-negative staphylococci (CoNS) in England over the recent 12-year period.

Methods: Laboratory confirmed CoNS reported from sterile sites in patients in England to the UK Health Security Agency (UKHSA) between 2010 and 2021 were extracted from the national laboratory database and analysed.

Results: Overall, 668,857 episodes of CoNS were reported. Unspeciated CoNS accounted for 56% (374,228) of episodes, followed by Staphylococcus epidermidis (26%; 174,050), S. hominis (6.5%; 43,501) and S. capitis (3.9%; 25,773). Unspeciated CoNS increased by 8.2% (95% CI, 7.1-9.3) annually between 2010 and 2016, then decreased annually by 6.4% (95% CI: -4.8 to -7.9) until 2021. Speciated CoNS increased by 47.6% (95% CI, 44.5-50.9) annually between 2010 and 2016 and increased annually by 8.9% (95% CI: 5.1 to 12.8) until 2021. Antimicrobial susceptibility profiles differed by species.

Conclusions: Reports of CoNS from normally sterile body sites in patients in England increased between 2010 and 2016 and remained stable between 2017 and 2021. There has been a striking improvement in species-level identification of CoNS in recent years. Monitoring trends in CoNS epidemiology is crucial for development of observational and clinical intervention studies on individual species.