1887

Abstract

Yeasts of the genera and are opportunist pathogens and cause oral lesions, especially in immunocompromised patients. This study assessed yeasts isolated from chronic kidney patients undergoing haemodialysis for their adhesion capacity, biofilm formation and susceptibility to antifungal agents. Ten isolates of spp. and one isolate of were tested for adhesion to buccal epithelial cells (BECs), adhesion and formation of biofilm in artificial saliva and their susceptibility profile to antifungal agents. Adhesion and biofilm formation were undertaken in polystyrene plates with artificial saliva, whilst susceptibility to antifungal agents was evaluated by broth microdilution. had the highest adhesion index in BECs (154.55 ± 22.13) and was the species with the highest adhesion capacity (18 398 Abs cm) in abiotic surface with artificial saliva. provided the greatest biofilm formation (2035 Abs cm ± 0.09) but was revealed to be susceptible to the five antifungal agents under analysis. However, some non- isolates showed a lower susceptibility for the antifungal agents itraconazole, fluconazole and voriconazole. All of the species were sensitive to amphotericin B and nystatin. The current analysis showed that yeasts isolated from the mouth of chronic kidney patients undergoing haemodialysis varied significantly with regard to their capacity for adherence, biofilm formation and susceptibility to antifungal agents, underscoring the high virulence of non- species.

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2015-09-01
2024-03-28
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