1887

Abstract

Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50 % of fatal cases, 25–50 % of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency ( mutation, a 32 bp deletion in the gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for and evaluated its correlation with patient mortality. patients (17.4 %) showed a higher mortality rate than WT individuals (4.7 %;  = 0.021), which indicates that patients are at higher risk than the normal population of a fatal outcome in influenza infection.

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2015-08-01
2024-03-29
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