1887

Abstract

causes symptoms of acute inflammatory diarrhoea in man. interaction with epithelial cells elicits interleukin-8 (IL-8) production, and IL-8 recruits neutrophils to sites of infection. Cell culture models of bacterial interaction with epithelium are useful to define bacteria–host interaction and are used because it is thought they mimic the same bacteria–host cell interaction in the natural disease. This study looks at the ability of strains to elicit IL-8 production from a variety of cell lines previously used for investigating the interaction of with host cells. A spectrum of IL-8 responses was observed, with minimal IL-8 elicited from Caco-2 cells and more marked responses elicited from HeLa and T84 cells. These -infected cell line responses were compared to IL-8 production from -infected human colonic and ileal tissue. The -infected tissue elicited the highest IL-8 responses and the cytokine was manifested earlier compared to the infected cell lines.

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2006-12-01
2019-10-23
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