RT Journal Article SR Electronic(1) A1 Murata, Masayuki A1 Azuma, Yoshinao A1 Miura, Koshiro A1 Rahman, Mohd. Akhlakur A1 Matsutani, Minenosuke A1 Aoyama, Masahiro A1 Suzuki, Harumi A1 Sugi, Kazuro A1 Shirai, MutsunoriYR 2007 T1 Chlamydial SET domain protein functions as a histone methyltransferase JF Microbiology, VO 153 IS 2 SP 585 OP 592 DO https://doi.org/10.1099/mic.0.29213-0 PB Microbiology Society, SN 1465-2080, AB SET domain genes have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. Herein, a Chlamydophila pneumoniae SET domain gene was clarified to be coincidently expressed with hctA and hctB genes encoding chlamydial histone H1-like proteins, Hc1 and Hc2, respectively. The SET domain protein (cpnSET) is localized in chlamydial cells and interacts with Hc1 and Hc2 through the C-terminal SET domain. As expected from conservation of catalytic sites in cpnSET, it functions as a protein methyltransferase to murine histone H3 and Hc1. However, little is known about protein methylation in the molecular pathogenesis of chlamydial infection. cpnSET may play an important role in chlamydial cell maturation due to modification of chlamydial histone H1-like proteins., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.29213-0