@article{mbs:/content/journal/micro/10.1099/mic.0.29213-0, author = "Murata, Masayuki and Azuma, Yoshinao and Miura, Koshiro and Rahman, Mohd. Akhlakur and Matsutani, Minenosuke and Aoyama, Masahiro and Suzuki, Harumi and Sugi, Kazuro and Shirai, Mutsunori", title = "Chlamydial SET domain protein functions as a histone methyltransferase", journal= "Microbiology", year = "2007", volume = "153", number = "2", pages = "585-592", doi = "https://doi.org/10.1099/mic.0.29213-0", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.29213-0", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "GST, glutathione S-transferase", keywords = "h.p.i., hours post-infection", keywords = "RB, reticulate body", keywords = "FCS, fetal calf serum", keywords = "EB, elementary body", keywords = "cpnSET, Chlamydophila pneumoniae SET domain protein", abstract = "SET domain genes have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. Herein, a Chlamydophila pneumoniae SET domain gene was clarified to be coincidently expressed with hctA and hctB genes encoding chlamydial histone H1-like proteins, Hc1 and Hc2, respectively. The SET domain protein (cpnSET) is localized in chlamydial cells and interacts with Hc1 and Hc2 through the C-terminal SET domain. As expected from conservation of catalytic sites in cpnSET, it functions as a protein methyltransferase to murine histone H3 and Hc1. However, little is known about protein methylation in the molecular pathogenesis of chlamydial infection. cpnSET may play an important role in chlamydial cell maturation due to modification of chlamydial histone H1-like proteins.", }