1887

Abstract

The genus contains over 80 recognized species, and is characterized by a high level of diversity, reflected in its complex phylogeny. The authors' recent determination of the genome sequence of means that five complete genomes of species are available for comparative genomics: , , , and . This paper now shows that there is no extensive synteny of the genome sequences of these five lactobacilli. Phylogeny based on whole-genome alignments suggested that was closer to than to , which was closest to , in contrast to 16S rRNA gene relatedness. A total of 593 orthologues common to all five species were identified. Species relatedness based on this protein set was largely concordant with genome synteny-based relatedness. A supertree, combining individual phylogenetic trees from each of 354 core proteins, had four main branches, comprising ; ; ; and . The extreme divergence of the genomes analysed supports the recognition of new subgeneric divisions.

Keyword(s): GI, gastrointestinal
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2006-11-01
2019-11-12
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