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Volume 152, Issue 9

AopP, a type III effector protein of , inhibits the NF-B signalling pathway Free

Abstract

subsp. contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The gene was detected in both typical and atypical isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-B) signalling pathways. AopP inhibits the NF-B pathway downstream of IB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.

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Keyword(s): EGF, epidermal growth factor , ERK, extracellular signal-regulated kinase , HA, haemagglutinin , IKK, IκB kinase , MAPK, mitogen-activated protein kinase , MKK, MAPK kinase , NF-κB, nuclear factor kappa B , TNF-α, tumour necrosis factor alpha , TTSS, type three secretion system and wt, wild-type
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2006-09-01
2024-04-25
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AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway
Microbiology 152, 2809 (2006); https://doi.org/10.1099/mic.0.28889-0
/content/journal/micro/10.1099/mic.0.28889-0
/content/journal/micro/10.1099/mic.0.28889-0
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