1887

Abstract

The AbrB protein is a DNA-binding global regulator of a plethora of functions that are expressed during the transition from exponential growth to stationary phase and under suboptimal growth conditions. AbrB orthologues have been identified in a variety of prokaryotic organisms, notably in all species of , and that have been examined. Based on amino acid sequence identity in the N-terminal domains of the orthologues from and , it was predicted that the proteins might display identical DNA-binding specificities. The binding of purified AbrB (AbrB) and purified AbrB (AbrB) at DNA targets of , and a synthetic origin was compared. In all cases examined, DNA-binding specificity was identical as judged by DNase I footprinting. In cells, the promoters from the and genes were regulated by AbrB, and the promoter from the operon was regulated by AbrB.

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2005-06-01
2019-10-17
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