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Volume 151, Issue 7

Multiple genotypes of identified in human carotid plaque Free

Abstract

is an obligate intracellular respiratory pathogen that causes 10 % of community-acquired pneumonia and has been associated with cardiovascular disease. Both whole-genome sequencing and specific gene typing suggest that there is relatively little genetic variation in human isolates of . To date, there has been little genomic analysis of strains from human cardiovascular sites. The genotypes of present in human atherosclerotic carotid plaque were analysed and several polymorphisms in the variable domain 4 (VD4) region of the outer-membrane protein-A () gene and the intergenic region between the and uridine kinase (–) genes were found. While one genotype was identified that was the same as one reported previously in humans (respiratory and cardiovascular), another genotype was found that was identical to a genotype from non-human sources (frog/koala).

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
Keyword(s): CAD, carotid artery disease , PBMCs, peripheral blood mononuclear cells and VD4, variable domain 4
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2005-07-01
2024-04-20
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Multiple genotypes of Chlamydia pneumoniae identified in human carotid plaque
Microbiology 151, 2285 (2005); https://doi.org/10.1099/mic.0.27781-0
/content/journal/micro/10.1099/mic.0.27781-0
/content/journal/micro/10.1099/mic.0.27781-0
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