1887

Abstract

The genes encode a sensor kinase and a response regulator forming a two-component system. is located downstream of , and belongs to the RND (esistance-odulation-ell ivision) superfamily, which is present in most major organisms. Four genes (, , and ) in belong to this family. This study revealed that the YdfHI two-component system regulates transcription. A gel shift assay using histidine-tagged YdfI (h-YdfI) showed that it directly binds to the promoter region. Moreover, DNase I footprinting analysis revealed a tandem repeat sequence consisting of two conserved 12-mer sequences (GCCCRAAYGTAC) within the h-YdfI-binding site.

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2005-06-01
2019-11-17
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