1887

Abstract

It was previously shown that downregulates carbon metabolism in upon glucose exhaustion, and that the gene is glucose repressed. Here, it is shown that glucose repression of is overcome upon nitrogen withdrawal, suggesting that is a regulator of carbon and nitrogen metabolism. -Galactosidase activity fostered by the promoter of /, which encode anabolic enzymes of nitrogen metabolism, was altered in an disruptant. As compared to the wild-type strain, the disruptant showed a decrease in the ratio of 2-oxoglutarate to glutamate under nitrogen-limited conditions. disruptants showed reduced pseudohyphal formation and enhanced sporulation, a phenomenon that occurs under conditions of both nitrogen and carbon withdrawal. These studies revealed that regulates carbon and nitrogen metabolism, as well as morphogenetic changes, suggesting that is a component of the link between the metabolic status of the cell and the corresponding developmental pathway.

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2005-01-01
2019-10-14
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