1887

Abstract

is an important pathogen of humans, causing a range of superficial and potentially life-threatening diseases. Infection of the fruit fly with results in systemic infection followed by death. Screening of defined mutants for components important in pathogenesis identified and , with fly death up to threefold slower after infection with the respective mutants compared to the wild-type. Infection of with reporter gene fusion strains demonstrated the expression levels of the accessory gene regulator, , -toxin, , and a manganese transporter, . The use of the green fluorescent protein as a reporter under the control of the promoter (P3) showed microcolony formation . The disease model also allowed the effect of antibiotic treatment on the flies to be determined. is a genetically tractable model host for high-throughput analysis of virulence determinants.

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2004-07-01
2020-08-14
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