1887

Abstract

is a human pathogen that is naturally transformable. In this study a major component of the homologous recombination pathway, the RexAB exonuclease/helicase, was characterized. and insertional mutants were constructed using mutagenesis and found to have identical phenotypes. Both mutants displayed poor cell viability, reduced double-strand exonuclease activity, UV sensitivity and a reduced level of gene conversion compared to the wild-type strain. No effect was observed on plasmid and chromosomal transformation efficiencies. These results indicate that in , RexAB is required for DNA repair, but not for chromosomal transformation and plasmid establishment.

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2004-07-01
2020-01-20
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