1887

Abstract

The plasminogen activator streptokinase has been proposed to be a key component of a complex mechanism that promotes skin invasion by . This study was designed to compare gene message and protein levels in wild-type M1 serotype isolate 1881 and a more invasive variant recovered from the spleen of a lethally infected mouse. M1 isolates selected for invasiveness demonstrated enhanced levels of active plasminogen activator activity in culture. This effect was due to a combination of increased expression of the gene and decreased expression of the gene. The gene product, SpeB, was found to efficiently degrade streptokinase .

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2004-02-01
2020-04-03
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