%0 Journal Article %A Vadyvaloo, Viveka %A Snoep, Jacky L. %A Hastings, John W. %A Rautenbach, Marina %T Physiological implications of class IIa bacteriocin resistance in Listeria monocytogenes strains %D 2004 %J Microbiology, %V 150 %N 2 %P 335-340 %@ 1465-2080 %R https://doi.org/10.1099/mic.0.26731-0 %K PTS, phosphoenolpyruvate-dependent phosphotransferase system %I Microbiology Society, %X High-level resistance to class IIa bacteriocins has been directly associated with the absent EIIABMan (MptA) subunit of the mannose-specific phosphoenolpyruvate-dependent phosphotransferase system (PTS) () in Listeria monocytogenes strains. Class IIa bacteriocin-resistant strains used in this study were a spontaneous resistant, L. monocytogenes B73-MR1, and a defined mutant, L. monocytogenes EGDe-mptA. Both strains were previously reported to have the EIIABMan PTS component missing. This study shows that these class IIa bacteriocin-resistant strains have significantly decreased specific growth and glucose consumption rates, but they also have a significantly higher growth yield than their corresponding wild-type strains, L. monocytogenes B73 and L. monocytogenes EGDe, respectively. In the presence of glucose, the strains showed a shift from a predominantly lactic-acid to a mixed-acid fermentation. It is here proposed that elimination of the EIIABMan in the resistant strains has caused a reduced glucose consumption rate and a reduced specific growth rate. The lower glucose consumption rate can be correlated to a shift in metabolism to a more efficient pathway with respect to ATP production per glucose, leading to a higher biomass yield. Thus, the cost involved in obtaining bacteriocin resistance, i.e. losing substrate transport capacity leading to a lower growth rate, is compensated for by a higher biomass yield. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.26731-0