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Volume 150, Issue 2

Role of the locus in Free

Abstract

The roles of two adjacent genes in the chromosome with functions in starvation survival and the response to stressful conditions have been characterized. One of these, , encoding a hypoxanthine–guanine phosphoribosyltransferase homologue, was initially identified in a transposon mutagenesis screen. Mutation of affects starvation survival in amino-acid-limiting conditions and the ability of to grow in high-salt concentrations. Downstream of is , which encodes a membrane-bound, ATP- and Zn-dependent ‘AAA’-type protease. Mutation of in leads to pleiotropic defects including slower growth, sensitivity to salt, acid, methyl viologen and potassium tellurite stresses, and reduced survival in amino-acid- or phosphate-limiting conditions. Both and gene fusions are expressed maximally in the post-exponential phase of growth. Although secretion of exoproteins is not affected, an mutant is attenuated in a murine skin lesion model of pathogenicity.

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  • Published Online:
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2004-02-01
2024-04-19
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Role of the hprT–ftsH locus in Staphylococcus aureus
Microbiology 150, 373 (2004); https://doi.org/10.1099/mic.0.26674-0
/content/journal/micro/10.1099/mic.0.26674-0
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