1887

Abstract

Differentiation in the spore-forming bacterium is governed by the sequential activation of five sporulation-specific transcription factors. The early mother-cell-specific transcription factor, , directs the transcription of many genes that contribute to the formation of mature, dormant spores. In this study, DNA microarrays were used to identify genes belonging to the regulon. In total, 171 genes were found to be under the control of . Of these, 101 genes had not previously been described as being dependent. Disruption of some of the previously unknown genes (, , , and ) resulted in a defect in sporulation.

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2003-10-01
2019-10-19
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