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Volume 154, Issue 8

Role of quorum sensing by in microbial keratitis and cystic fibrosis Free

Abstract

is a ubiquitous bacterium that causes opportunistic infections in a range of host tissues and organs. Infections by are difficult to treat and hence there is interest in the development of effective therapeutics. One of the key mechanisms that uses to control the expression of many virulence factors is the -acylated homoserine lactone (AHL) regulatory system. Hence, there is considerable interest in targeting this regulatory pathway to develop novel therapeutics for infection control. is the principal cause of microbial keratitis and of infections in cystic fibrosis (CF) sufferers, and AHL-dependent cell-to-cell signalling has been shown to be important for both infection types. However, keratitis tends to be an acute infection whereas infection of CF patients develops into a chronic, life-long infection. Thus, it is unclear whether AHL-regulated virulence plays the same role during these infections. This review presents a comparison of the role of AHL signalling in -mediated microbial keratitis and chronic lung infections of CF patients.

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Keyword(s): 3O-C12-HSL, N-3-oxododecanoyl-l-homoserine lactone , AHL, acylated homoserine lactone , C4-HSL, N-butyryl-l-homoserine lactone , C6-HSL, N-hexanoyl-l-homoserine lactone; CF, cystic fibrosis , MK, microbial keratitis , PMN, polymorphonuclear leukocyte , PQS, Pseudomonas quinolone signal and QS, quorum sensing
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Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis
Microbiology 154, 2184 (2008); https://doi.org/10.1099/mic.0.2008/019281-0
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/content/journal/micro/10.1099/mic.0.2008/019281-0
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