1887

Abstract

The adaptation of to elevated levels of copper ions requires the copper-inducible operon encoding a copper chaperone and efflux ATPase. Here we identify CsoR (formerly YvgZ) as the copper-sensing repressor that regulates the operon. CsoR binds with high affinity to an operator site overlapping the promoter and its binding is specifically inhibited by copper salts. As previously described, the YhdQ (CueR) protein also binds to the regulatory region, but genetic experiments indicate that this protein is not responsible for the copper-dependent regulation of this operon.

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2007-12-01
2019-11-12
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