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Volume 153, Issue 10

Identification of a signalling molecule involved in bacterial intergeneric communication Free

Abstract

The development of complex multispecies communities such as biofilms is controlled by interbacterial communication systems. We have previously reported an intergeneric communication between two oral bacteria, and , that results in inhibition of expression. Here, we demonstrate that a surface protein, arginine deiminase (ArcA), of serves as a signal that initiates intergeneric communication. An ArcA-deficient mutant of is unable to communicate with . Furthermore, arginase activity is not essential for the communication, and ArcA retains the ability to repress expression of in the presence of arginine deiminase inhibitors. These results present a novel mechanism by which intergeneric communication in dental biofilms is accomplished.

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
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2007-10-01
2023-06-08
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Identification of a signalling molecule involved in bacterial intergeneric communication
Microbiology 153, 3228 (2007); https://doi.org/10.1099/mic.0.2007/009050-0
/content/journal/micro/10.1099/mic.0.2007/009050-0
/content/journal/micro/10.1099/mic.0.2007/009050-0
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