1887

Abstract

The development of complex multispecies communities such as biofilms is controlled by interbacterial communication systems. We have previously reported an intergeneric communication between two oral bacteria, and , that results in inhibition of expression. Here, we demonstrate that a surface protein, arginine deiminase (ArcA), of serves as a signal that initiates intergeneric communication. An ArcA-deficient mutant of is unable to communicate with . Furthermore, arginase activity is not essential for the communication, and ArcA retains the ability to repress expression of in the presence of arginine deiminase inhibitors. These results present a novel mechanism by which intergeneric communication in dental biofilms is accomplished.

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2007-10-01
2020-03-29
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