1887

Abstract

The gene was identified in a signature-tagged mutagenesis screen for Tn insertions attenuated for mouse virulence, and subsequently found to be defective in expression. Its attenuation of virulence was attributed to its failure to express the regulon. In addition to the Tn insertion in , the original mutant strain (P6C63) has an adventitious frame-shift in , which results in truncation of the AgrC peptide. Separation of the mutation from the frame-shift revealed that has no detectable affect on activation, as assessed by exoprotein profiles and the production of haemolytic toxins. These results indicate that does not play a role in infections via an -mediated pathway.

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2007-05-01
2020-09-21
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