RT Journal Article SR Electronic(1) A1 Kulkarni, Heramb M. A1 Jagannadham, Medicharla V.YR 2014 T1 Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria JF Microbiology, VO 160 IS 10 SP 2109 OP 2121 DO https://doi.org/10.1099/mic.0.079400-0 PB Microbiology Society, SN 1465-2080, AB Outer membrane vesicles (OMVs) released from Gram-negative bacteria consist of lipids, proteins, lipopolysaccharides and other molecules. OMVs are associated with several biological functions such as horizontal gene transfer, intracellular and intercellular communication, transfer of contents to host cells, and eliciting an immune response in host cells. Although hypotheses have been made concerning the mechanism of biogenesis of these vesicles, research on OMV formation is far from complete. The roles of outer membrane components, bacterial quorum sensing molecules and some specific proteins in OMV biogenesis have been studied. This review discusses the different models that have been proposed for OMV biogenesis, along with details of the biological functions of OMVs and the likely scope of future research., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.079400-0