1887

Abstract

The heterocystous cyanobacterium sp. strain PCC 7120 grows as linear multicellular filaments that can contain hundreds of cells. Heterocysts, which are specialized cells for nitrogen fixation, are regularly intercalated among photosynthetic vegetative cells, and these cells are metabolically dependent on each other. Thus, multicellularity is essential for diazotrophic growth of heterocystous cyanobacteria. In sp. strain PCC 7120, the gene, which is required to limit filament length, is induced by nitrogen deprivation. The transcripts extend to the gene, which lies on the opposite DNA strand and could possess dual functionality, mRNAs for and antisense RNAs for . In the present study, we found that NrrA, a nitrogen-regulated response regulator, directly regulated expression of . Induction of by nitrogen deprivation was abolished by the disruption. NrrA specifically bound to the promoter region of , and recognized an inverted repeat sequence. Thus, it is concluded that NrrA controls expression of mRNAs for and antisense RNAs for in response to nitrogen deprivation.

Funding
This study was supported by the:
  • , Japan Science and Technology Agency
  • , Japan Society for the Promotion of Science , (Award 23603005)
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2014-05-01
2021-03-09
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