1887

Abstract

is a Gram-positive bacterium that is indigenous to the oral cavity. , a primary colonizer of the oral cavity, serves as a tether for the attachment of other oral pathogens. The colonization of microbes on the tooth surface forms dental plaque, which can lead to the onset of periodontal disease. We examined a comprehensive mutant library to identify genes related to cellular chain length and morphology using phase-contrast microscopy. A number of hypothetical genes related to the cellular chain length were identified in this study. Genes related to the cellular chain length were analysed along with clusters of orthologous groups (COG) for gene functions. It was discovered that the highest proportion of COG functions related to cellular chain length was ‘cell division and chromosome separation’. However, different COG functions were also found to be related with altered cellular chain length. This suggested that different genes related with multiple mechanisms contribute to the cellular chain length in SK36.

Funding
This study was supported by the:
  • National Institutes of Health (Award R01DE023078 and R01DE018138)
  • Virginia Commonwealth University Presidential Research
  • Incentive Program (Award 144602-3)
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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/content/journal/micro/10.1099/mic.0.071688-0
2014-02-01
2024-12-14
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