1887

Abstract

The regulation and control of gene expression in response to differing environmental stimuli is crucial for successful pathogen adaptation and persistence. The regulatory gene of encodes a stand-alone response regulator with similarity to the Mga of group A . Mga controls expression of a number of important virulence determinants. Experimental intramammary challenge of dairy cattle with a mutant of carrying an inactivating lesion in showed reduced ability to colonize the mammary gland and an inability to induce clinical signs of mastitis compared with the wild-type strain. Analysis of transcriptional differences of gene expression in the mutant, determined by microarray analysis, identified a number of coding sequences with altered expression in the absence of Vru. These consisted of known and putative virulence determinants, including Lbp (Sub0145), SclB (Sub1095), PauA (Sub1785) and (Sub1696).

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2012-06-01
2019-10-13
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