1887

Abstract

The virulence profiles of quorum-sensing (QS) mutants were assessed in feeding and nicking infection models. Functional RhlIR and LasIR QS systems were required for killing in the fly feeding infection model but were not essential in the fly nicking infection model. Mixed infections between PAO1 and strains harbouring mutations in , and resulted in increased lethality in the fly feeding model compared with either isolate alone. These results suggested that the parental strain could cooperate with QS mutants in the feeding infection model. Finally, the mixed infection between PAO1 and an mutant resulted in spiteful behaviour and reduced pathogenicity of the mixed culture.

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2012-08-01
2019-11-13
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